BCL2-Associated Athanogene 5 (BAG5) (AA 1-448) antibody

Details for Product No. ABIN393381
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Antigen
Synonyms BAG5, zgc:114117, bag-5, BAG-5, 1600025G07Rik, 4930405J06Rik
Epitope
AA 1-448
(16), (8), (8), (7), (4), (2), (1), (1), (1)
Reactivity
Human
(69), (20), (20), (13), (12), (2)
Host
Mouse
(51), (16), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(53), (31), (12), (10), (4), (4), (4), (2), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393381
450.00 $
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Immunogen BAG5 (AAH50551, 1 a.a. ~ 448 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E2
Isotype IgG1 kappa
Specificity BAG5 (AAH50551, 1 a.a. ~ 448 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BAG5
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 51200 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-BCL2-Associated Athanogene 5 (BAG5) (AA 1-448) antibody BAG5 monoclonal antibody (M01), clone 2E2 Western Blot analysis of BAG5 expression in Jurkat.
Background publications Kalia, Lee, Smith et al.: "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration." in: Neuron, Vol. 44, Issue 6, pp. 931-45, 2004 (PubMed).

Talmud, Drenos, Shah et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

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