BCL2-Associated Athanogene 5 (BAG5) antibody

Antigen: BCL2-Associated Athanogene 5 (BAG5)

Synonyms: BAG-5, 1600025G07Rik, 4930405J06Rik, MGC95040, BAG5, MGC133732, MGC114117, zgc:114117, bag-5

Clonality: Monoclonal (2E2)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393381

Additional Information

Alternative name: BAG5

Gene ID: 9529

Immunogen: BAG5 (AAH50551, 1 a.a. ~ 448 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 2E2

Description: Other names: BAG5, KIAA0873 BCL2-associated athanogene 5

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: BAG5 (AAH50551, 1 a.a. ~ 448 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 51200 DA

Comments:

Background: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

BAG5 monoclonal antibody (M01), clone 2E2 Western Blot analysis of BAG5 expression in Jurkat ( Cat # L017V1 ).

Publications

Product: Kalia, Lee, Smith et al.: "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration." in: Neuron, Vol. 44, Issue 6, pp. 931-45, 2004 (PubMed).

Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).