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SCY1-Like 1 (S. Cerevisiae) (SCYL1) (AA 373-472) antibody

Details for Product No. ABIN393395
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Antigen
Synonyms DDBDRAFT_0189357, DDBDRAFT_0220502, DDB_0189357, DDB_0220502, GKLP, NKTL, NTKL, P105, TAPK, TEIF, TRAP, 2810011O19Rik, C85140, Ntkl, mdf, mfd, p105
Epitope
AA 373-472
(8), (7), (2), (2), (1), (1)
Reactivity
Human
(22), (1), (1)
Host
Mouse
(15), (7)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(20), (14), (8), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393395
450.00 $
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Immunogen SCYL1 (AAH09967, 373 a.a. ~ 472 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E5
Isotype IgG2a kappa
Specificity SCYL1 (AAH09967, 373 a.a. ~ 472 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCYL1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 89631 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-SCY1-Like 1 (S. Cerevisiae) (SCYL1) (AA 373-472) antibody SCYL1 monoclonal antibody (M02), clone 2E5. Western Blot analysis of SCYL1 expression in Hela NE.
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Burman, Bourbonniere, Philie et al.: "Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic." in: The Journal of biological chemistry, Vol. 283, Issue 33, pp. 22774-86, 2008 (PubMed).

Gong, Sun, McNutt et al.: "Localization of TEIF in the centrosome and its functional association with centrosome amplification in DNA damage, telomere dysfunction and human cancers." in: Oncogene, Vol. 28, Issue 12, pp. 1549-60, 2009 (PubMed).

Yan, Zhang, Di et al.: "A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination." in: FEBS letters, Vol. 584, Issue 15, pp. 3275-8, 2010 (PubMed).

Validation Images
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