SCYL1 antibody (SCY1-Like 1 (S. Cerevisiae)) (AA 373-472)

Details for Product anti-SCYL1 Antibody No. ABIN393395, Supplier: Log in to see
Antigen
  • DDBDRAFT_0189357
  • DDBDRAFT_0220502
  • DDB_0189357
  • DDB_0220502
  • GKLP
  • NKTL
  • NTKL
  • P105
  • TAPK
  • TEIF
  • TRAP
  • 2810011O19Rik
  • C85140
  • Ntkl
  • mdf
  • mfd
  • p105
  • N-terminal kinase-like protein
  • SCY1-like 1 (S. cerevisiae)
  • SCY1-like 1
  • scy1
  • PITG_12105
  • SCYL1
  • scyl1
  • Scyl1
Alternatives
anti-Human SCYL1 antibody for ELISA
Epitope
AA 373-472
18
9
3
2
1
1
1
1
1
Reactivity
Human
38
3
2
2
2
1
1
Host
Mouse
29
9
Clonality (Clone)
Monoclonal ()
Conjugate
This SCYL1 antibody is un-conjugated
3
3
3
3
3
3
Application
Western Blotting (WB)
35
23
20
5
3
2
2
1
1
Options
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Immunogen SCYL1 (AAH09967, 373 a.a. ~ 472 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E5
Isotype IgG2a kappa
Specificity SCYL1 (AAH09967, 373 a.a. ~ 472 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SCYL1 (SCYL1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 89631 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Pathways p53 Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SCYL1 antibody (SCY1-Like 1 (S. Cerevisiae)) (AA 373-472) (ABIN393395) SCYL1 monoclonal antibody (M02), clone 2E5. Western Blot analysis of SCYL1 expression...
Background publications Yan, Zhang, Di, Shi, Rao, Huo: "A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination." in: FEBS letters, Vol. 584, Issue 15, pp. 3275-8, 2010 (PubMed).

Gong, Sun, McNutt, Sun, Hou, Liu, Shen, Ling, Chi, Zhang: "Localization of TEIF in the centrosome and its functional association with centrosome amplification in DNA damage, telomere dysfunction and human cancers." in: Oncogene, Vol. 28, Issue 12, pp. 1549-60, 2009 (PubMed).

Burman, Bourbonniere, Philie, Stroh, Dejgaard, Presley, McPherson: "Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic." in: The Journal of biological chemistry, Vol. 283, Issue 33, pp. 22774-86, 2008 (PubMed).

Barbe, Lundberg, Oksvold, Stenius, Lewin, Björling, Asplund, Pontén, Brismar, Uhlén, Andersson-Svahn: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).