Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) (AA 232-268) antibody

Details for Product No. ABIN393398
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Antigen
Synonyms
ARABIDOPSIS THALIANA PLANT UNCOUPLING MITOCHONDRIAL PROTEIN 1, ARABIDOPSIS THALIANA UNCOUPLING PROTEIN 1, ATPUMP1, ATUCP1, UCP, UCP1, UNCOUPLING PROTEIN 1, plant uncoupling mitochondrial protein 1, uc ... show more
ARABIDOPSIS THALIANA PLANT UNCOUPLING MITOCHONDRIAL PROTEIN 1, ARABIDOPSIS THALIANA UNCOUPLING PROTEIN 1, ATPUMP1, ATUCP1, UCP, UCP1, UNCOUPLING PROTEIN 1, plant uncoupling mitochondrial protein 1, ucp, slc25a7, SLC25A7, AI385626, Slc25a7, Ucp, Ucpa, Uncp show less
Epitope
AA 232-268
(13), (5), (3), (3), (1), (1), (1), (1)
Reactivity
Human
(37), (27), (19), (14), (12), (1)
Host
Mouse
(42), (7), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(43), (29), (11), (10), (6), (5), (5), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393398
450.00 $
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Immunogen UCP1 (NP_068605, 232 a.a. ~ 268 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4E5
Isotype IgG2a kappa
Specificity UCP1 (NP_068605, 232 a.a. ~ 268 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name UCP1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 33005 DA
Gene ID 12406
NCBI Accession NP_068605
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) (AA 232-268) antibody Detection limit for recombinant GST tagged UCP1 is approximately 0.3 ng/mL as a capture antibody.
Background publications Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Wang, Li, Glessner et al.: "Large copy-number variations are enriched in cases with moderate to extreme obesity." in: Diabetes, Vol. 59, Issue 10, pp. 2690-4, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Hancock, Clark, Qian et al.: "Population genetic analysis of the uncoupling proteins supports a role for UCP3 in human cold resistance." in: Molecular biology and evolution, Vol. 28, Issue 1, pp. 601-14, 2010 (PubMed).

Kim, Lee: "The effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on weight loss and lipid profiles in obese women." in: International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition, Vol. 80, Issue 2, pp. 87-96, 2010 (PubMed).

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