Ubiquitin-Conjugating Enzyme E2R 2 (UBE2R2) (AA 1-239) antibody

Details for Product No. ABIN393400
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Antigen
Synonyms zgc:92307, UBE2R2, cdc34b, e2-cdc34b, ubc3b, CDC34B, E2-CDC34B, UBC3B, 1200003M11Rik, Cdc34b, Ubc3b
Epitope
AA 1-239
(9), (6), (6), (2), (1), (1), (1), (1)
Reactivity
Human
(33), (14), (13), (12)
Host
Mouse
(24), (7), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(21), (15), (10), (4), (2), (1), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393400
450.00 $
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Immunogen UBE2R2 (AAH47584, 1 a.a. ~ 239 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5E7
Isotype IgG2b kappa
Specificity UBE2R2 (AAH47584, 1 a.a. ~ 239 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name UBE2R2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 27166 DA
Gene ID 12406
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Ubiquitin-Conjugating Enzyme E2R 2 (UBE2R2) (AA 1-239) antibody UBE2R2 monoclonal antibody (M01), clone 5E7 Western Blot analysis of UBE2R2 expression in Jurkat. Detection limit for recombinant GST tagged UBE2R2 is approximately 0.1 ng/mL as a capture antibody.
anti-Ubiquitin-Conjugating Enzyme E2R 2 (UBE2R2) (AA 1-239) antibody (2) anti-Ubiquitin-Conjugating Enzyme E2R 2 (UBE2R2) (AA 1-239) antibody (Image 2)
Background publications Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Ferreira, ODonovan, Meng et al.: "Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder...." in: Nature genetics, Vol. 40, Issue 9, pp. 1056-8, 2009 (PubMed).

Oguri, Kato, Yokoi et al.: "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals." in: American journal of hypertension, Vol. 23, Issue 1, pp. 70-7, 2009 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Validation Images
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