Ubiquitin-Conjugating Enzyme E2R 2 (UBE2R2) antibody

Antigen: Ubiquitin-Conjugating Enzyme E2R 2 (UBE2R2)

Synonyms: UBC3B, CDC34B, FLJ20419, MGC10481, zgc:92307, UBE2R2, xubc3, Ubc3b, Cdc34b, 1200003M11Rik, ubc3b, cdc34b, MGC147593

Clonality: Monoclonal (5E7)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393400

Additional Information

Alternative name: UBE2R2

Gene ID: 54926

Immunogen: UBE2R2 (AAH47584, 1 a.a. ~ 239 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2b kappa

Clone: 5E7

Description: Other names: CDC34B, FLJ20419, MGC10481, UBC3B ubiquitin-conjugating enzyme E2R 2

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: UBE2R2 (AAH47584, 1 a.a. ~ 239 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 27166 DA

Comments:

Background: Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

UBE2R2 monoclonal antibody (M01), clone 5E7 Western Blot analysis of UBE2R2 expression in Jurkat ( Cat # L017V1 ). Detection limit for recombinant GST tagged UBE2R2 is approximately 0.1ng/ml as a capture antibody.

anti-Ubiquitin-Conjugating Enzyme E2R 2 (UBE2R2) antibody (Image 2)

Publications

Product: Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Ferreira, ODonovan, Meng et al.: "Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder." in: Nature genetics, Vol. 40, Issue 9, pp. 1056-8, 2009 (PubMed).

Oguri, Kato, Yokoi et al.: "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals." in: American journal of hypertension, Vol. 23, Issue 1, pp. 70-7, 2009 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).