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Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like (MTHFD1L) (AA 801-900) antibody

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Synonyms FTHFSDC1, MTC1THFS, dJ292B18.2, Fthfsdc1, 2410004L15Rik, AI647056
AA 801-900
(4), (3), (2), (2), (1), (1)
(22), (11), (11), (3), (2), (2), (1), (1), (1), (1), (1), (1)
(12), (7), (3)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB)
(21), (12), (10), (3), (2), (1), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen MTHFD1L (NP_056255, 801 a.a. ~ 900 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E8
Isotype IgG2a kappa
Specificity MTHFD1L (NP_056255, 801 a.a. ~ 900 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MTHFD1L (MTHFD1L Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 105790 DA
Gene ID 12406
NCBI Accession NP_056255
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000

Background: One-carbon substituted forms of tetrahydrofolate (THF) are involved in the de novo synthesis of purines and thymidylate and support cellular methylation reactions through the regeneration of methionine from homocysteine. MTHFD1L is an enzyme involved in THF synthesis in mitochondria (Christensen et al., 2005 [PubMed 15611115]).

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like (MTHFD1L) (AA 801-900) antibody (ABIN393402) MTHFD1L monoclonal antibody (M01), clone 1E8 Western Blot analysis of MTHFD1L express...
Background publications Roder, Peters, Kasuya et al.: "Common genetic polymorphisms in moyamoya and atherosclerotic disease in Europeans." in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, Vol. 27, Issue 2, pp. 245-52, 2011 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Bressler, Folsom, Couper et al.: "Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study." in: American journal of epidemiology, Vol. 171, Issue 1, pp. 14-23, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Parle-McDermott, Pangilinan, OBrien et al.: "A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency." in: Human mutation, Vol. 30, Issue 12, pp. 1650-6, 2009 (PubMed).

Catalog No. ABIN393402
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