Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like (MTHFD1L) antibody

Details for Product No. ABIN393402
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Antigen
Synonyms FTHFSDC1, MTC1THFS, dJ292B18.2, 2410004L15Rik, AI647056, Fthfsdc1
Reactivity
Human
(10), (5), (4), (1), (1), (1)
Host
Mouse
(5), (3), (2)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(10), (7), (4), (1)
Pubmed 5 references available
Catalog no. ABIN393402
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen MTHFD1L (NP_056255, 801 a.a. ~ 900 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E8
Isotype IgG2a kappa
Specificity MTHFD1L (NP_056255, 801 a.a. ~ 900 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MTHFD1L
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 105790 DA
Gene ID 12406
UniProt NP_056255
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: One-carbon substituted forms of tetrahydrofolate (THF) are involved in the de novo synthesis of purines and thymidylate and support cellular methylation reactions through the regeneration of methionine from homocysteine. MTHFD1L is an enzyme involved in THF synthesis in mitochondria (Christensen et al., 2005 [PubMed 15611115]).

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like (MTHFD1L) antibody MTHFD1L monoclonal antibody (M01), clone 1E8 Western Blot analysis of MTHFD1L expression in PC-12.
Background publications Parle-McDermott, Pangilinan, OBrien et al.: "A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency." in: Human mutation, Vol. 30, Issue 12, pp. 1650-6, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Bressler, Folsom, Couper et al.: "Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study." in: American journal of epidemiology, Vol. 171, Issue 1, pp. 14-23, 2009 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Roder, Peters, Kasuya et al.: "Common genetic polymorphisms in moyamoya and atherosclerotic disease in Europeans." in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, Vol. 27, Issue 2, pp. 245-52, 2011 (PubMed).

Hosts (5), (3), (2)
Reactivities (10), (5), (4), (1), (1), (1)
Applications (10), (7), (4), (1)
Epitopes (2), (2), (2)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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