Arylacetamide Deacetylase (Esterase) (AADAC) (AA 201-301) antibody

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Antigen
Synonyms MGC89272, AADAC, CES5A1, DAC, Aada, 5033417E09Rik, AI265437
Epitope
AA 201-301
(5), (2), (2), (2), (1), (1)
Reactivity
Human
(29), (14), (13), (13), (12), (2), (1)
Host
Mouse
(26), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(20), (10), (7), (5), (4), (3)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393404
450.00 $
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Immunogen AADAC (NP_001077, 201 a.a. ~ 301 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E8
Isotype IgG2b kappa
Specificity AADAC (NP_001077, 201 a.a. ~ 301 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AADAC
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 45748 DA
Gene ID 12406
NCBI Accession NP_001077
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Arylacetamide Deacetylase (Esterase) (AADAC) (AA 201-301) antibody Detection limit for recombinant GST tagged AADAC is approximately 3 ng/mL as a capture antibody.
Background publications Ross, Crow: "Human carboxylesterases and their role in xenobiotic and endobiotic metabolism." in: Journal of biochemical and molecular toxicology, Vol. 21, Issue 4, pp. 187-96, 2007 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Watanabe, Fukami, Nakajima et al.: "Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 37, Issue 7, pp. 1513-20, 2009 (PubMed).

Saito, Kawamoto, Kamatani: "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects." in: Journal of human genetics, Vol. 54, Issue 6, pp. 317-23, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

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