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Cyclin-Dependent Kinase Inhibitor 2D (p19, Inhibits CDK4) (CDKN2D) (AA 1-167) antibody

Details for Product No. ABIN393412
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Antigen
Synonyms ink4d, p19, p19-ink4d, CDKN2D, ank2, INK4D, p19-INK4D, INK4d, p19INK4d
Epitope
AA 1-167
(7), (7), (4), (1), (1)
Reactivity
Human
(49), (12), (12)
Host
Mouse
(28), (21)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(29), (16), (14), (11), (10), (9), (7), (5), (4), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393412
450.00 $
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Immunogen CDKN2D (AAH01822, 1 a.a. ~ 167 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E10
Isotype IgG2b kappa
Specificity CDKN2D (AAH01822, 1 a.a. ~ 167 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CDKN2D
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 17700 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Cyclin-Dependent Kinase Inhibitor 2D (p19, Inhibits CDK4) (CDKN2D) (AA 1-167) antibody Western Blot analysis of CDKN2D expression in transfected 293T cell line by CDKN2D monoclonal antibody (M08), clone 2E10. Lane 1: CDKN2D transfected lysate(17.7 KDa). Lane 2: Non-transfected lysate.
Background publications Mavaddat, Dunning, Ponder et al.: "Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 1, pp. 255-9, 2009 (PubMed).

Agarwal, Mateo, Marx: "Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states." in: The Journal of clinical endocrinology and metabolism, Vol. 94, Issue 5, pp. 1826-34, 2009 (PubMed).

Goode, Fridley, Vierkant et al.: "Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 3, pp. 935-44, 2009 (PubMed).

Zhang, Zeng, Zhou et al.: "Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis." in: Acta biochimica et biophysica Sinica, Vol. 41, Issue 5, pp. 414-28, 2009 (PubMed).

Cunningham, Vierkant, Sellers et al.: "Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis." in: British journal of cancer, Vol. 101, Issue 8, pp. 1461-8, 2009 (PubMed).

Validation Images
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