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Details for Product No. ABIN393413

WNK Lysine Deficient Protein Kinase 2 (WNK2) antibody

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Antigen
Synonyms
NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43, ESTM15, X83337, AW122246, mKIAA1760, 1810073P09Rik, ARABIDOPSIS THALIANA WITH NO K 2, ATWNK2, PROTEIN KINASE, ZIK3, with no lysine (K) kinase 2, RGD1307284, WNK ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393413
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen WNK2 (NP_006639, 2118 a.a. ~ 2218 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E10
Isotype IgG1 kappa
Specificity WNK2 (NP_006639, 2118 a.a. ~ 2218 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WNK2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 242676 DA
Gene ID 12406
UniProt NP_006639
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Jun, Hong, Lal et al.: "Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific." in: Neuro-oncology, Vol. 11, Issue 4, pp. 414-22, 2009 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of gene polymorphisms with chronic kidney disease in Japanese individuals." in: International journal of molecular medicine, Vol. 24, Issue 4, pp. 539-47, 2009 (PubMed).

Oguri, Kato, Yokoi et al.: "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals." in: American journal of hypertension, Vol. 23, Issue 1, pp. 70-7, 2009 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Alternatives for antigen "WNK Lysine Deficient Protein Kinase 2 (WNK2)", type "Antibodies"
Hosts (7), (3)
Reactivities (6), (4)
Applications (10), (8), (2)
Conjugates (1), (1), (1)
Epitopes (3), (2)
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