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MAP2K5 antibody (Mitogen-Activated Protein Kinase Kinase 5) (Met11)

Details for Product anti-MAP2K5 Antibody No. ABIN393416, Supplier: Log in to see
Antigen
  • AI324775
  • AI428457
  • ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5
  • ATMAP2K_ALPHA
  • ATMEK5
  • ATMKK5
  • fb73f02
  • HsT17454
  • MAP2K_A
  • MAP KINASE KINASE 5
  • MAP kinase kinase 5
  • MAPKK5
  • Mapkk5
  • Mek5
  • MEK5
  • PRKMK5
  • Prkmk5
  • wu:fb73f02
  • zgc:172137
Alternatives
anti-Human MAP2K5 antibody for Western Blotting
Epitope
Met11
32
31
17
17
15
13
13
13
13
6
5
5
4
3
3
2
2
2
2
2
1
1
1
1
Reactivity
Human
153
76
75
11
9
7
6
5
3
3
3
3
2
2
1
Host
Mouse
155
15
Clonality (Clone)
Monoclonal ()
Conjugate
This MAP2K5 antibody is un-conjugated
9
9
9
5
5
5
5
5
5
5
5
4
4
4
4
Application
Immunofluorescence (IF), Western Blotting (WB)
110
54
47
29
23
20
4
2
2
1
1
Supplier
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Immunogen MAP2K5 (AAH08838, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E10
Isotype IgG1 kappa
Specificity MAP2K5 (AAH08838, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAP2K5 (MAP2K5 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50112 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Pathways MAPK Signaling, Neurotrophin Signaling Pathway
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-MAP2K5 antibody (Mitogen-Activated Protein Kinase Kinase 5) (Met11) (ABIN393416) Immunofluorescence of monoclonal antibody to MAP2K5 on HeLa cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-MAP2K5 antibody (Mitogen-Activated Protein Kinase Kinase 5) (Met11) (ABIN393416) anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Met11) antibody (Image 2)
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Kripke, Shadan, Dawson, Cronin, Jamil, Grizas, Koziol, Kline: "Genotyping sleep disorders patients." in: Psychiatry investigation, Vol. 7, Issue 1, pp. 36-42, 2010 (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Rivière, Xiong, Levchenko, St-Onge, Gaspar, Dion, Lespérance, Tellier, Richer, Chouinard, Rouleau,: "Association of intronic variants of the BTBD9 gene with Tourette syndrome." in: Archives of neurology, Vol. 66, Issue 10, pp. 1267-72, 2009 (PubMed).

Spiering, Schmolke, Ohnesorge, Schmidt, Goebeler, Wegener, Wixler, Ludwig: "MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 24972-80, 2009 (PubMed).