|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Met11) antibody
|Synonyms||MEK5, MAPKK5, PRKMK5, HsT17454, Mapkk5, Prkmk5, AI324775, AI428457, Mek5, map2k5, fb73f02, MGC172137, wu:fb73f02|
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||MAP2K5 (AAH08838, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: HsT17454, MAPKK5, MEK5, PRKMK5 mitogen-activated protein kinase kinase 5|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||MAP2K5 (AAH08838, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||50112 DA|
Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure|
|Restrictions||For Research Use only|
Spiering, Schmolke, Ohnesorge et al.: "MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 24972-80, 2009 (PubMed).
Rivière, Xiong, Levchenko et al.: "Association of intronic variants of the BTBD9 gene with Tourette syndrome." in: Archives of neurology, Vol. 66, Issue 10, pp. 1267-72, 2009 (PubMed).
Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).
Kripke, Shadan, Dawson et al.: "Genotyping sleep disorders patients." in: Psychiatry investigation, Vol. 7, Issue 1, pp. 36-42, 2010 (PubMed).
Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).