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Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Met11) antibody

Details for Product No. ABIN393416
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Antigen
Synonyms
Mek5, HsT17454, MAPKK5, MEK5, PRKMK5, AI324775, AI428457, Mapkk5, Prkmk5, fb73f02, wu:fb73f02, zgc:172137, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5, ATMAP2K_ALPHA, ATMEK5, ATMKK5 ... show more
Mek5, HsT17454, MAPKK5, MEK5, PRKMK5, AI324775, AI428457, Mapkk5, Prkmk5, fb73f02, wu:fb73f02, zgc:172137, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5, ATMAP2K_ALPHA, ATMEK5, ATMKK5, MAP KINASE KINASE 5, MAP kinase kinase 5, MAP2K_A show less
Epitope
Met11
(24), (24), (13), (12), (12), (9), (8), (7), (6), (5), (4), (3), (3), (2), (2), (2), (1), (1)
Reactivity
Human
(118), (65), (58), (57), (42), (41), (24), (4), (4), (2), (1), (1), (1), (1)
Host
Mouse
(122), (10)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (7), (7), (5), (5), (5), (5), (5), (5), (5), (5), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(82), (50), (39), (21), (12), (9), (9), (5), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393416
450.00 $
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Immunogen MAP2K5 (AAH08838, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E10
Isotype IgG1 kappa
Specificity MAP2K5 (AAH08838, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAP2K5
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50112 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Met11) antibody Immunofluorescence of monoclonal antibody to MAP2K5 on HeLa cell (antibody concentration 10 µg/mL). MAP2K5 monoclonal antibody (M11), clone 3E10 Western Blot analysis of MAP2K5 expression in Jurkat.
anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Met11) antibody (2) anti-Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5) (Met11) antibody (Image 2)
Background publications Spiering, Schmolke, Ohnesorge et al.: "MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 24972-80, 2009 (PubMed).

Rivière, Xiong, Levchenko et al.: "Association of intronic variants of the BTBD9 gene with Tourette syndrome." in: Archives of neurology, Vol. 66, Issue 10, pp. 1267-72, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Kripke, Shadan, Dawson et al.: "Genotyping sleep disorders patients." in: Psychiatry investigation, Vol. 7, Issue 1, pp. 36-42, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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