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Ezrin (EZR) (AA 1-587) antibody

Details for Product No. ABIN393422, Supplier: Log in to see
Antigen
  • ezr
  • vil2
  • wu:fc05c03
  • wu:fj31d06
  • cvil
  • cvl
  • CVIL
  • CVL
  • VIL2
  • AW146364
  • R75297
  • Vil2
  • p81
  • ATVLN2
  • T11A7.16
  • T11A7_16
  • villin 2
Epitope
AA 1-587
28
28
23
23
22
21
14
14
11
8
6
5
5
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
316
178
156
13
10
8
5
4
3
3
3
3
2
2
Host
Mouse
260
30
25
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
11
9
8
5
5
5
4
4
4
4
4
4
2
1
1
Application
Western Blotting (WB)
248
103
62
45
41
23
6
5
5
3
3
1
1
1
Supplier
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Immunogen VIL2 (AAH13903, 1 a.a. ~ 587 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E11
Isotype IgG2b kappa
Specificity VIL2 (AAH13903, 1 a.a. ~ 587 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VIL2 (EZR Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 69413 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure, Cancer
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ezrin (EZR) (AA 1-587) antibody (ABIN393422) VIL2 monoclonal antibody (M04), clone 1E11. Western Blot analysis of VIL2 expression ...
Background publications Tuna, Yorukoglu, Mazzucchelli et al.: "Ezrin immunoreactivity in renal cell carcinomas." in: Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology, Vol. 31, Issue 5, pp. 340-4, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Boldrini, Peres, Morini et al.: "Immunoexpression of Ezrin and CD44 in patients with osteosarcoma." in: Journal of pediatric hematology/oncology, Vol. 32, Issue 6, pp. e213-7, 2010 (PubMed).

Machado, Navarro, Giner et al.: "Ezrin immunohistochemical expression in chondrosarcomas, osteosarcomas and Ewing sarcoma family of tumors." in: Virchows Archiv : an international journal of pathology, Vol. 457, Issue 1, pp. 87-9, 2010 (PubMed).