Ezrin (EZR) antibody

Details for Product No. ABIN393422
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Antigen
Synonyms CVIL, CVL, VIL2, Vil2, AW146364, R75297, p81, ATVLN2, T11A7.16, T11A7_16, villin 2, ezr, vil2, wu:fc05c03, wu:fj31d06, cvil, cvl
Reactivity
Human
(248), (176), (152), (52), (40), (36), (36), (12), (2), (2)
Host
Mouse
(220), (22), (10)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Western Blotting (WB)
(201), (97), (50), (50), (31), (16), (6), (4), (3), (2), (1), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN393422
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen VIL2 (AAH13903, 1 a.a. ~ 587 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1E11
Isotype IgG2b kappa
Specificity VIL2 (AAH13903, 1 a.a. ~ 587 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VIL2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 69413 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure, Cancer
Application Notes Western blot = 1:500-1000
Comment

Background: The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Ezrin (EZR) antibody VIL2 monoclonal antibody (M04), clone 1E11. Western Blot analysis of VIL2 expression in HepG2.
Background publications Machado, Navarro, Giner et al.: "Ezrin immunohistochemical expression in chondrosarcomas, osteosarcomas and Ewing sarcoma family of tumors." in: Virchows Archiv : an international journal of pathology, Vol. 457, Issue 1, pp. 87-9, 2010 (PubMed).

Boldrini, Peres, Morini et al.: "Immunoexpression of Ezrin and CD44 in patients with osteosarcoma." in: Journal of pediatric hematology/oncology, Vol. 32, Issue 6, pp. e213-7, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Tuna, Yorukoglu, Mazzucchelli et al.: "Ezrin immunoreactivity in renal cell carcinomas." in: Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology, Vol. 31, Issue 5, pp. 340-4, 2010 (PubMed).

Hosts (220), (22), (10)
Reactivities (248), (176), (152), (52), (40), (36), (36), (12), (2), (2)
Applications (201), (97), (50), (50), (31), (16), (6), (4), (3), (2), (1), (1), (1), (1)
Conjugates (8), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (32), (24), (22), (21), (17), (13), (12), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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