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AKT antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 1) (AA 1-481)

Details for Product anti-AKT1 Antibody No. ABIN393423, Supplier: Log in to see
Antigen
  • AKT
  • AKT1
  • pkb
  • xAct
  • v-akt
  • v-akt1
  • akt-1
  • AKT/PKB
  • Akt
  • Akt/PKB
  • Akt1
  • PKB
  • CG4006
  • D-Akt
  • DAKT1
  • DAKT1/PKB
  • DAkt
  • DAkt1
  • DPKB
  • DRAC-PK
  • DRAC-PK66
  • DRAC-PK85
  • Dakt
  • Dakt1
  • Dmel\\CG4006
  • Dpkb
  • PKB/AKT
  • PKB/Akt
  • PKB/dAKT
  • RAC
  • RacPK
  • akt
  • akt1
  • dAKT
  • dAKT/dPKB
  • dAKT1
  • dAkt
  • dAkt/PKB
  • dAkt1
  • dPKB
  • dakt
  • dakt1
  • l(3)04226
  • l(3)89Bq
  • p-Akt
  • pAkt
  • ATAKT1
  • F18A8.2
  • F18A8_2
  • K+ transporter 1
  • POTASSIUM TRANSPORTER
  • Rac
  • PKBalpha
  • CWS6
  • PKB-ALPHA
  • PRKBA
  • RAC-ALPHA
Alternatives
anti-Human AKT antibody for Western Blotting
Epitope
AA 1-481
144
114
88
86
55
39
39
38
21
21
20
19
18
16
15
15
14
13
13
11
11
10
8
7
6
6
6
5
5
5
5
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
1069
483
390
43
42
31
30
20
17
15
10
6
5
4
2
2
1
1
1
Host
Mouse
882
208
14
4
1
Clonality (Clone)
Monoclonal ()
Conjugate
This AKT antibody is un-conjugated
39
32
32
31
26
24
10
5
5
4
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
881
510
415
200
110
107
107
65
43
36
33
12
11
6
3
3
3
3
1
1
1
1
1
Supplier
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Immunogen AKT1 (AAH00479, 1 a.a. ~ 481 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2E11
Isotype IgG2a kappa
Specificity AKT1 (AAH00479, 1 a.a. ~ 481 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AKT1 (AKT1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 55686 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Pathways PI3K-Akt Signaling, RTK Signaling, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Western blot = 1:500-1000
Comment

Background: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-AKT antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 1) (AA 1-481) (ABIN393423) Immunofluorescence of monoclonal antibody to AKT1 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-AKT antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 1) (AA 1-481) (ABIN393423) anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (AA 1-481) antibody (Image 2)
Background publications Izquierdo, Truan, Mengual et al.: "HER-2/AKT expression in upper urinary tract urothelial carcinoma: prognostic implications." in: Anticancer research, Vol. 30, Issue 6, pp. 2439-45, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Lin, Lin, Yu: "miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells." in: Molecular carcinogenesis, Vol. 49, Issue 8, pp. 719-27, 2010 (PubMed).

Slattery, Herrick, Lundgreen et al.: "Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1." in: Carcinogenesis, Vol. 31, Issue 9, pp. 1604-11, 2010 (PubMed).

Benesch, Schneider, Voelker et al.: "The clinicopathological and prognostic relevance of pyruvate kinase M2 and pAkt expression in breast cancer." in: Anticancer research, Vol. 30, Issue 5, pp. 1689-94, 2010 (PubMed).

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