Fas (TNFRSF6) Associated Factor 1 (FAF1) (AA 551-651) antibody

Details for Product No. ABIN393433
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Antigen
Synonyms faf1, MGC53741, MGC80303, FAF1, zgc:55752, wu:fc25h12, HFAF1s, UBXD12, UBXN3A, hFAF1, AA408698, Dffrx, Fam
Epitope
AA 551-651
(18), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(54), (38), (38), (12), (12), (12)
Host
Mouse
(50), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(43), (23), (10), (10), (6), (4), (3), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393433
450.00 $
Plus shipping costs $45.00

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Immunogen FAF1 (NP_008982, 551 a.a. ~ 651 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1A10
Isotype IgG1 kappa
Specificity FAF1 (NP_008982, 551 a.a. ~ 651 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FAF1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 73954 DA
Gene ID 12406
NCBI Accession NP_008982
Research Area Ubiquitin-related antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) (AA 551-651) antibody Immunofluorescence of monoclonal antibody to FAF1 on HeLa cell (antibody concentration 30 µg/mL). FAF1 monoclonal antibody (M01), clone 1A10 Western Blot analysis of FAF1 expression in HeLa.
anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) (AA 551-651) antibody (2) anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) (AA 551-651) antibody (Image 2)
Background publications Shin, Kang, Lee et al.: "Crystallization and preliminary X-ray crystallographic analysis of the N domain of p97/VCP in complex with the UBX domain of FAF1." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 66, Issue Pt 1, pp. 41-3, 2010 (PubMed).

Kang, Shin, Yang: "Crystallization and preliminary X-ray crystallographic analysis of human FAF1 UBX domain." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 66, Issue Pt 2, pp. 211-3, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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