Fas (TNFRSF6) Associated Factor 1 (FAF1) antibody

Antigen: Fas (TNFRSF6) Associated Factor 1 (FAF1)

Synonyms: hFAF1, CGI-03, HFAF1s, UBXD12, UBXN3A, FLJ37524, faf1, MGC53741, MGC80303, FAF1, MGC137718, zgc:55752, wu:fc25h12

Clonality: Monoclonal (1A10)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393433

Additional Information

Alternative name: FAF1

Gene ID: 11124

UniProt: NP_008982

Immunogen: FAF1 (NP_008982, 551 a.a. ~ 651 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 1A10

Description: Other names: CGI03, HFAF1s, hFAF1Fas (TNFRSF6) associated factor 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: FAF1 (NP_008982, 551 a.a. ~ 651 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 73954 DA

Comments:

Background: Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Concentration: 1 mg/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Ubiquitin-related antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of monoclonal antibody to FAF1 (AT1991a) on HeLa cell . [antibody concentration 30 ug/ml] FAF1 monoclonal antibody (M01), clone 1A10 Western Blot analysis of FAF1 expression in HeLa ( Cat # L013V1 ).

anti-Fas (TNFRSF6) Associated Factor 1 (FAF1) antibody (Image 2)

Publications

Product: Shin, Kang, Lee et al.: "Crystallization and preliminary X-ray crystallographic analysis of the N domain of p97/VCP in complex with the UBX domain of FAF1." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 66, Issue Pt 1, pp. 41-3, 2010 (PubMed).

Kang, Shin, Yang: "Crystallization and preliminary X-ray crystallographic analysis of human FAF1 UBX domain." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 66, Issue Pt 2, pp. 211-3, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).