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F-Box and Leucine-Rich Repeat Protein 3 (FBXL3) (AA 1-101) antibody

Details for Product No. ABIN393439, Supplier: Login to see
Antigen
  • fbxl3
  • FBXL3
  • FBL3
  • FBL3A
  • FBXL3A
  • AU041772
  • AW212966
  • FBK
  • Fbl3a
  • Fbxl3a
  • Ovtm
  • Play68
  • F7A7.240
  • F7A7_240
Epitope
AA 1-101
19
6
3
3
3
2
2
2
1
1
1
1
Reactivity
Human
49
31
18
6
3
1
1
1
1
1
1
Host
Mouse
32
20
6
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
46
24
11
8
4
4
3
2
2
1
Supplier
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Immunogen FBXL3 (NP_036290, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1A3
Isotype IgG2a kappa
Specificity FBXL3 (NP_036290, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FBXL3 (FBXL3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 48707 DA
Gene ID 12406
NCBI Accession NP_036290
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-F-Box and Leucine-Rich Repeat Protein 3 (FBXL3) (AA 1-101) antibody (ABIN393439) FBXL3 monoclonal antibody (M03), clone 1A3. Western Blot analysis of FBXL3 expression...
Background publications Busino, Bassermann, Maiolica et al.: "SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins." in: Science (New York, N.Y.), Vol. 316, Issue 5826, pp. 900-4, 2007 (PubMed).

Kimura, Wakamatsu, Suzuki et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." in: Genome research, Vol. 16, Issue 1, pp. 55-65, 2006 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Ilyin, Rialland, Pigeon et al.: "cDNA cloning and expression analysis of new members of the mammalian F-box protein family." in: Genomics, Vol. 67, Issue 1, pp. 40-7, 2000 (PubMed).