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Ring Finger Protein 125 (RNF125) (AA 143-232) antibody

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Synonyms 4930553F04Rik, TRAC-1, TRAC1
AA 143-232
(5), (3), (3), (3), (2), (2), (2), (2), (1), (1)
(49), (28), (26), (4), (4), (4), (2), (2), (1), (1), (1), (1)
(39), (7), (5)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(31), (20), (11), (8), (4), (3), (1), (1)
Pubmed 5 references available
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Quantity 0.1 mg
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Availability Will be delivered in 8 to 11 Business Days
Immunogen RNF125 (NP_060301, 143 a.a. ~ 232 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1A5
Isotype IgG1 kappa
Specificity RNF125 (NP_060301, 143 a.a. ~ 232 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RNF125 (RNF125 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 26454 DA
Gene ID 12406
NCBI Accession NP_060301
Research Area Ubiquitin-related antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: This gene encodes a novel E3 ubiquitin ligase that contains an N-terminal RING finger domain. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Ring Finger Protein 125 (RNF125) (AA 143-232) antibody (ABIN393443) Detection limit for recombinant GST tagged RNF125 is approximately 0.03 ng/mL as a ca...
Background publications Giannini, Gao, Bijlmakers: "T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain." in: The Biochemical journal, Vol. 410, Issue 1, pp. 101-11, 2008 (PubMed).

Arimoto, Konishi, Shimotohno: "UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I." in: Molecular immunology, Vol. 45, Issue 4, pp. 1078-84, 2007 (PubMed).

Shoji-Kawata, Zhong, Kameoka et al.: "The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells." in: Virology, Vol. 368, Issue 1, pp. 191-204, 2007 (PubMed).

Zhao, Li, Pardo et al.: "A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 9, pp. 5288-97, 2005 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Catalog No. ABIN393443
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