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Ring Finger Protein 125 (RNF125) antibody

Details for Product No. ABIN393443
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Antigen
Synonyms TRAC-1, TRAC1, 4930553F04Rik
Reactivity
Human
(34), (23), (23), (15), (3), (2), (2), (2), (1), (1)
Host
Mouse
(29), (4), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(23), (16), (10), (7), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393443
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen RNF125 (NP_060301, 143 a.a. ~ 232 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1A5
Isotype IgG1 kappa
Specificity RNF125 (NP_060301, 143 a.a. ~ 232 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RNF125
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 26454 DA
Gene ID 12406
UniProt NP_060301
Research Area Ubiquitin-related antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a novel E3 ubiquitin ligase that contains an N-terminal RING finger domain. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Ring Finger Protein 125 (RNF125) antibody Detection limit for recombinant GST tagged RNF125 is approximately 0.03 ng/mL as a capture antibody.
Background publications Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Zhao, Li, Pardo et al.: "A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 9, pp. 5288-97, 2005 (PubMed).

Shoji-Kawata, Zhong, Kameoka et al.: "The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells." in: Virology, Vol. 368, Issue 1, pp. 191-204, 2007 (PubMed).

Arimoto, Konishi, Shimotohno: "UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I." in: Molecular immunology, Vol. 45, Issue 4, pp. 1078-84, 2007 (PubMed).

Giannini, Gao, Bijlmakers: "T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain." in: The Biochemical journal, Vol. 410, Issue 1, pp. 101-11, 2008 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN393443
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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