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AKT2 antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 2) (AA 100-189)

Details for Product anti-AKT2 Antibody No. ABIN393457, Supplier: Log in to see
Antigen
  • AKT2
  • pkbb
  • pkbbeta
  • pkbss
  • prkbb
  • rac-beta
  • v-akt2
  • 2410016A19Rik
  • AW554154
  • PKB
  • PKBbeta
  • HIHGHH
  • PKBB
  • PKBBETA
  • PRKBB
  • RAC-BETA
  • cb945
  • akt2-a
Alternatives
anti-Human AKT2 antibody for ELISA
Epitope
AA 100-189
55
41
41
30
25
16
10
10
7
6
5
5
4
4
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
387
124
100
30
28
25
24
21
21
19
19
19
19
1
1
1
Host
Mouse
302
69
12
10
3
2
Clonality (Clone)
Monoclonal ()
Conjugate
This AKT2 antibody is un-conjugated
19
19
18
16
15
15
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
333
219
144
79
42
25
25
21
19
12
11
4
4
3
1
1
1
Supplier
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Immunogen AKT2 (AAA58364, 100 a.a. ~ 189 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1B3
Isotype IgG1 kappa
Specificity AKT2 (AAA58364, 100 a.a. ~ 189 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AKT2 (AKT2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 55769 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Pathways PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, TLR Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-AKT2 antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 2) (AA 100-189) (ABIN393457) Immunofluorescence of monoclonal antibody to AKT2 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-AKT2 antibody (V-Akt Murine Thymoma Viral Oncogene Homolog 2) (AA 100-189) (ABIN393457) anti-V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) (AA 100-189) antibody (Image 2)
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Pu, Hildebrandt, Lu et al.: "PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy." in: Lung cancer (Amsterdam, Netherlands), Vol. 71, Issue 1, pp. 82-8, 2010 (PubMed).

Foley, Bray, Tivnan et al.: "MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2." in: Molecular cancer, Vol. 9, pp. 83, 2010 (PubMed).

Wickenden, Watson: "Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts." in: Breast cancer research : BCR, Vol. 12, Issue 2, pp. 202, 2010 (PubMed).

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