V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) (AA 100-189) antibody

Details for Product No. ABIN393457
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Antigen
Synonyms AKT2, pkbb, pkbbeta, pkbss, prkbb, rac-beta, v-akt2, 2410016A19Rik, AW554154, PKB, PKBbeta, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, cb945, akt2-a
Epitope
AA 100-189
(41), (24), (21), (17), (16), (10), (7), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(260), (98), (80), (12), (8), (6), (4), (4), (4), (2), (2), (2), (2), (1), (1), (1)
Host
Mouse
(189), (63), (10), (3), (2), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (8), (8), (7), (7), (7), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(247), (124), (111), (47), (39), (36), (15), (12), (12), (11), (10), (10), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393457
450.00 $
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Immunogen AKT2 (AAA58364, 100 a.a. ~ 189 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1B3
Isotype IgG1 kappa
Specificity AKT2 (AAA58364, 100 a.a. ~ 189 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AKT2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 55769 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) (AA 100-189) antibody Immunofluorescence of monoclonal antibody to AKT2 on HeLa cell (antibody concentration 10 µg/mL). AKT2 monoclonal antibody (M01), clone 1B3 Western Blot analysis of AKT2 expression in Jurkat.
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) (AA 100-189) antibody (2) anti-V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) (AA 100-189) antibody (Image 2)
Background publications Wickenden, Watson: "Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts." in: Breast cancer research : BCR, Vol. 12, Issue 2, pp. 202, 2010 (PubMed).

Foley, Bray, Tivnan et al.: "MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2." in: Molecular cancer, Vol. 9, pp. 83, 2010 (PubMed).

Pu, Hildebrandt, Lu et al.: "PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy." in: Lung cancer (Amsterdam, Netherlands), Vol. 71, Issue 1, pp. 82-8, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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