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NFKBIB antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta) (AA 56-145)

Details for Product anti-NFKBIB Antibody No. ABIN393462, Supplier: Login to see
Antigen
  • NFKBIB
  • IKB-beta
  • IKappaBbeta
  • IkB
  • IkBb
  • IKBB
  • TRIP9
Alternatives
anti-Human NFKBIB antibody for Western Blotting
Epitope
AA 56-145
33
29
15
12
9
6
5
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
155
66
56
4
4
Host
Mouse
135
24
Clonality (Clone)
Monoclonal ()
Conjugate
This NFKBIB antibody is un-conjugated
5
5
4
4
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
110
63
57
26
25
19
13
8
3
3
1
1
Supplier
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Immunogen NFKBIB (AAH15528, 56 a.a. ~ 145 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1B5
Isotype IgG2a kappa
Specificity NFKBIB (AAH15528, 56 a.a. ~ 145 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NFKBIB (NFKBIB Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 37771 DA
Gene ID 12406
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways NF-kappaB Signaling
Application Notes ELISA ~~ 1ug/ml~3ng/ml Immunohistochemistry ~~ 1.5ug/ml
Comment

Background: NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-NFKBIB antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta) (AA 56-145) (ABIN393462) Immunoperoxidase of monoclonal antibody to NFKBIB on formalin-fixed paraffin-embedded...
Immunohistochemistry (IHC) image for anti-NFKBIB antibody (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta) (AA 56-145) (ABIN393462) anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, beta (NFKBIB) (AA 56-145) antibody (Image 2)
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Potter, Cordell, Barton et al.: "Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways." in: Annals of the rheumatic diseases, Vol. 69, Issue 7, pp. 1315-20, 2010 (PubMed).

Segat, Brandão, Guimarães et al.: "Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment." in: Vaccine, Vol. 28, Issue 10, pp. 2201-6, 2010 (PubMed).

McGeachie, Ramoni, Mychaleckyj et al.: "Integrative predictive model of coronary artery calcification in atherosclerosis." in: Circulation, Vol. 120, Issue 24, pp. 2448-54, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

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