Oxidative-Stress Responsive 1 (OXSR1) (Met19) antibody

Details for Product No. ABIN393465
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Antigen
Synonyms zgc:55494, zgc:77321, OXSR1, OSR1, Osr1, 2210022N24Rik, 2810422B09Rik, AI462649, AW209236, mKIAA1101
Epitope
Met19
(12), (8), (7), (7), (7), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(71), (29), (17), (13), (12), (12), (1)
Host
Mouse
(42), (37)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(66), (45), (21), (16), (12), (11), (10), (10), (10), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393465
450.00 $
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Immunogen OXSR1 (AAH08726, 1 a.a. ~ 528 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1B9
Isotype IgG2a kappa
Specificity OXSR1 (AAH08726, 1 a.a. ~ 528 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name OXSR1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58022 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Oxidative-Stress Responsive 1 (OXSR1) (Met19) antibody Immunofluorescence of monoclonal antibody to OXSR1 on HeLa cell (antibody concentration 10 µg/mL). OXSR1 monoclonal antibody (M19), clone 1B9 Western Blot analysis of OXSR1 expression in Hela NE.
anti-Oxidative-Stress Responsive 1 (OXSR1) (Met19) antibody (2) anti-Oxidative-Stress Responsive 1 (OXSR1) (Met19) antibody (Image 2)
Background publications Villa, Goebel, Rafiqi et al.: "Structural insights into the recognition of substrates and activators by the OSR1 kinase." in: EMBO reports, Vol. 8, Issue 9, pp. 839-45, 2007 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Richardson, Rafiqi, Karlsson et al.: "Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1." in: Journal of cell science, Vol. 121, Issue Pt 5, pp. 675-84, 2008 (PubMed).

Villa, Deak, Alessi et al.: "Structure of the OSR1 kinase, a hypertension drug target." in: Proteins, Vol. 73, Issue 4, pp. 1082-7, 2008 (PubMed).

Lee, Cobb, Goldsmith: "Crystal structure of domain-swapped STE20 OSR1 kinase domain." in: Protein science : a publication of the Protein Society, Vol. 18, Issue 2, pp. 304-13, 2009 (PubMed).

Validation Images
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