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Histone Deacetylase 11 (HDAC11) (AA 1-348) antibody

Details for Product No. ABIN393476, Supplier: Log in to see
Antigen
  • CG31119
  • DHDACX
  • Dmel\\CG31119
  • HDAC11
  • HDACX
  • dHDAC11
  • dmHDA403
  • zgc:91942
  • HD11
Epitope
AA 1-348
23
21
16
15
9
5
5
3
2
2
1
1
1
1
1
1
Reactivity
Human
90
38
13
1
1
1
Host
Mouse
87
18
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
6
6
6
6
6
6
1
Application
Immunofluorescence (IF), Western Blotting (WB)
96
53
36
8
7
4
3
2
1
1
Supplier
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Immunogen HDAC11 (AAH09676, 1 a.a. ~ 348 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C2-2G5
Isotype IgG1 kappa
Specificity HDAC11 (AAH09676, 1 a.a. ~ 348 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HDAC11 (HDAC11 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39183 DA
Gene ID 12406
Research Area Signaling, Protein Modifications, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Histone Deacetylase 11 (HDAC11) (AA 1-348) antibody (ABIN393476) Immunofluorescence of monoclonal antibody to HDAC11 on HeLa cell.[antibody concentrat...
Immunohistochemistry (IHC) image for anti-Histone Deacetylase 11 (HDAC11) (AA 1-348) antibody (ABIN393476) anti-Histone Deacetylase 11 (HDAC11) (AA 1-348) antibody (Image 2)
Background publications Janssen, Schmalbach, Boeselt et al.: "Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 6, pp. 573-81, 2010 (PubMed).

Glozak, Seto: "Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11446-53, 2009 (PubMed).

Georgopoulos: "From immunity to tolerance through HDAC." in: Nature immunology, Vol. 10, Issue 1, pp. 13-4, 2008 (PubMed).

Villagra, Cheng, Wang et al.: "The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance." in: Nature immunology, Vol. 10, Issue 1, pp. 92-100, 2008 (PubMed).

Fournel, Bonfils, Hou et al.: "MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo." in: Molecular cancer therapeutics, Vol. 7, Issue 4, pp. 759-68, 2008 (PubMed).