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Histone Deacetylase 11 (HDAC11) (AA 1-348) antibody

Details for Product No. ABIN393476
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Antigen
Synonyms CG31119, DHDACX, Dmel\\CG31119, HDAC11, HDACX, dHDAC11, dmHDA403, zgc:91942, HD11
Epitope
AA 1-348
(11), (11), (8), (8), (7), (3), (3), (2), (1), (1)
Reactivity
Human
(63), (29), (18), (12), (12), (1), (1), (1)
Host
Mouse
(62), (9)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(61), (36), (18), (10), (10), (7), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN393476
450.00 $
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Immunogen HDAC11 (AAH09676, 1 a.a. ~ 348 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C2-2G5
Isotype IgG1 kappa
Specificity HDAC11 (AAH09676, 1 a.a. ~ 348 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HDAC11
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39183 DA
Gene ID 12406
Research Area Signaling, Protein Modifications, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Histone Deacetylase 11 (HDAC11) (AA 1-348) antibody Immunofluorescence of monoclonal antibody to HDAC11 on HeLa cell.[antibody concentration 10 µg/mL] HDAC11 monoclonal antibody (M01), clone 1C2-2G5 Western Blot analysis of HDAC11 expression in HL-60.
anti-Histone Deacetylase 11 (HDAC11) (AA 1-348) antibody (2) anti-Histone Deacetylase 11 (HDAC11) (AA 1-348) antibody (Image 2)
Background publications Fournel, Bonfils, Hou et al.: "MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo." in: Molecular cancer therapeutics, Vol. 7, Issue 4, pp. 759-68, 2008 (PubMed).

Villagra, Cheng, Wang et al.: "The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance." in: Nature immunology, Vol. 10, Issue 1, pp. 92-100, 2008 (PubMed).

Georgopoulos: "From immunity to tolerance through HDAC." in: Nature immunology, Vol. 10, Issue 1, pp. 13-4, 2008 (PubMed).

Glozak, Seto: "Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11446-53, 2009 (PubMed).

Janssen, Schmalbach, Boeselt et al.: "Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 6, pp. 573-81, 2010 (PubMed).

Validation Images
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