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Details for Product No. ABIN393476

Histone Deacetylase 11 (HDAC11) antibody

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Synonyms HD11, CG31119, DHDACX, Dmel\\CG31119, HDAC11, HDACX, dHDAC11, dmHDA403, zgc:91942
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393476
Quantity 0.1 mg
450.00 $   Plus shipping costs $45.00
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Immunogen HDAC11 (AAH09676, 1 a.a. ~ 348 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1C2-2G5
Isotype IgG1 kappa
Specificity HDAC11 (AAH09676, 1 a.a. ~ 348 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HDAC11
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39183 DA
Gene ID 12406
Research Area Signaling, Protein Modifications, Chromatin, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Background: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Fournel, Bonfils, Hou et al.: "MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo." in: Molecular cancer therapeutics, Vol. 7, Issue 4, pp. 759-68, 2008 (PubMed).

Villagra, Cheng, Wang et al.: "The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance." in: Nature immunology, Vol. 10, Issue 1, pp. 92-100, 2008 (PubMed).

Georgopoulos: "From immunity to tolerance through HDAC." in: Nature immunology, Vol. 10, Issue 1, pp. 13-4, 2008 (PubMed).

Glozak, Seto: "Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11446-53, 2009 (PubMed).

Janssen, Schmalbach, Boeselt et al.: "Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 6, pp. 573-81, 2010 (PubMed).

Alternatives for antigen "Histone Deacetylase 11 (HDAC11)", type "Antibodies"
Hosts (47), (3)
Reactivities (46), (31), (19), (12), (12), (1), (1), (1)
Applications (40), (15), (10), (9), (6), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (5), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)