Histone Deacetylase 11 (HDAC11) antibody

Antigen: Histone Deacetylase 11 (HDAC11)

Synonyms: HD11, FLJ22237, MGC27683, HDAC11, MGC148838, CG31119, DHDACX, DmelCG31119, dmHDA403

Clonality: Monoclonal (1C2-2G5)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393476

Additional Information

Alternative name: HDAC11

Gene ID: 79885

Immunogen: HDAC11 (AAH09676, 1 a.a. ~ 348 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 1C2-2G5

Description: Other names: FLJ22237 histone deacetylase 11

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: HDAC11 (AAH09676, 1 a.a. ~ 348 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 39183 DA

Comments:

Background: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Signaling, Protein Modifications, Chromatin, Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of monoclonal antibody to HDAC11 (AT2338a) on HeLa cell.[antibody concentration 10ug/ml] HDAC11 monoclonal antibody (M01), clone 1C2-2G5 Western Blot analysis of HDAC11 expression in HL-60 ( Cat # L014V1 ).

anti-Histone Deacetylase 11 (HDAC11) antibody (Image 2)

Publications

Product: Fournel, Bonfils, Hou et al.: "MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo." in: Molecular cancer therapeutics, Vol. 7, Issue 4, pp. 759-68, 2008 (PubMed).

Villagra, Cheng, Wang et al.: "The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance." in: Nature immunology, Vol. 10, Issue 1, pp. 92-100, 2008 (PubMed).

Georgopoulos: "From immunity to tolerance through HDAC." in: Nature immunology, Vol. 10, Issue 1, pp. 13-4, 2008 (PubMed).

Glozak, Seto: "Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11446-53, 2009 (PubMed).

Janssen, Schmalbach, Boeselt et al.: "Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 6, pp. 573-81, 2010 (PubMed).