Mitogen-Activated Protein Kinase 1 (MAPK1) (AA 261-361) antibody

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Antigen
Synonyms
MAPK1, Xp42, erk, erk2, ert1, mapk, mapk1b, mapk2, mpk1, p42mapk, prkm1, prkm2, p38, p40, p41, xp42, p41mapk, Ephb2, Erk, elk, Erk2, ERK1, ERT2, Erk-1, Esrk1, MNK1, Prkm3, p44, p44erk1, p44mapk, ERK,  ... show more
MAPK1, Xp42, erk, erk2, ert1, mapk, mapk1b, mapk2, mpk1, p42mapk, prkm1, prkm2, p38, p40, p41, xp42, p41mapk, Ephb2, Erk, elk, Erk2, ERK1, ERT2, Erk-1, Esrk1, MNK1, Prkm3, p44, p44erk1, p44mapk, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, 9030612K14Rik, AA407128, AU018647, C78273, Prkm1, mapk1, mapk1a, ATMPK1, F14N23.9, F14N23_9, MITOGEN-ACTIVATED PROTEIN KINASE, mitogen-activated protein kinase 1, zERK2, ATMPK2, MITOGEN-ACTIVATED PROTEIN KINASE HOMOLOG 2, T30E16.13, T30E16_13, mitogen-activated protein kinase homolog 2 show less
Epitope
AA 261-361
(56), (17), (17), (10), (9), (9), (9), (5), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(230), (68), (65), (15), (13), (4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(149), (102), (7), (4), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (3), (3), (3), (3), (2), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(237), (101), (74), (53), (49), (38), (17), (16), (13), (11), (9), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393485
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Immunogen MAPK1 (AAH17832, 261 a.a. ~ 361 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D1
Isotype IgG1 kappa
Specificity MAPK1 (AAH17832, 261 a.a. ~ 361 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAPK1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41390 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase 1 (MAPK1) (AA 261-361) antibody Immunofluorescence of monoclonal antibody to MAPK1 on HeLa cell (antibody concentration 10 µg/mL). MAPK1 monoclonal antibody (M01), clone 1D1 Western Blot analysis of MAPK1 expression in Hela NE.
anti-Mitogen-Activated Protein Kinase 1 (MAPK1) (AA 261-361) antibody (2) anti-Mitogen-Activated Protein Kinase 1 (MAPK1) (AA 261-361) antibody (Image 2)
Background publications Kang, Banfield: "Pseudorabies virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated kinase (ERK) to membranes through interaction with the ERK common docking domain." in: Journal of virology, Vol. 84, Issue 17, pp. 8398-408, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Lujan, Hakim, Moyano et al.: "Activation of the EGFR/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands." in: British journal of cancer, Vol. 103, Issue 4, pp. 510-6, 2010 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Validation Images
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