Growth Arrest and DNA-Damage-Inducible, gamma (GADD45G) antibody

Antigen: Growth Arrest and DNA-Damage-Inducible, gamma (GADD45G)

Synonyms: CR6, DDIT2, GRP17, GADD45gamma, PRG6, CRIF1, CKBBP2, Plinp1, MGC4667, MGC4758, PLINP-1, MGC77806, GADD45G, cr6, ddit2, grp17, MGC89481, xgadd45g, gadd45gamma, XGadd45-gamma, MGC137546, OIG37, C86281, AI327420

Clonality: Monoclonal (1D3)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393489

Additional Information

Alternative name: GADD45G

Gene ID: 10912

Immunogen: GADD45G (AAH19325, 1 a.a. ~ 160 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 1D3

Description: Other names: CR6, DDIT2, GADD45gamma, GRP17 growth arrest and DNA-damage-inducible, gamma

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: GADD45G (AAH19325, 1 a.a. ~ 160 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 17121 DA

Comments:

Background: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta.

Synonyms: CR6, DDIT2, GRP17, GADD45gamma, PRG6, CRIF1, CKBBP2, Plinp1, MGC4667, MGC4758, PLINP-1, MGC77806, GADD45G, cr6, ddit2, grp17, MGC89481, xgadd45g, gadd45gamma, XGadd45-gamma, MGC137546, OIG37, C86281, AI327420

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged GADD45G is approximately 0.03ng/ml as a capture antibody.

Publications

Product: Zhang, Zhao, Li et al.: "Purification, crystallization and preliminary X-ray diffraction analysis of human Gadd45gamma." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 64, Issue Pt 11, pp. 1070-3, 2008 (PubMed).

Zhu, Shao, Xu et al.: "Gadd45-alpha and Gadd45-gamma utilize p38 and JNK signaling pathways to induce cell cycle G2/M arrest in Hep-G2 hepatoma cells." in: Molecular biology reports, Vol. 36, Issue 8, pp. 2075-85, 2009 (PubMed).

Palmieri, Wilson, Iversen et al.: "Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 17, Issue 12, pp. 3567-72, 2008 (PubMed).

Yu, Cho, Park et al.: "Urinary GADD45gamma expression is associated with progression of lgA nephropathy." in: American journal of nephrology, Vol. 30, Issue 2, pp. 135-9, 2009 (PubMed).

Zhang, Li, Shao et al.: "Semi-quantitative detection of GADD45-gamma methylation levels in gastric, colorectal and pancreatic cancers using methylation-sensitive high-resolution melting analysis." in: Journal of cancer research and clinical oncology, Vol. 136, Issue 8, pp. 1267-73, 2010 (PubMed).