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s100 antibody (S100 Calcium Binding Protein A1) (AA 1-76)

Details for Product anti-S100A1 Antibody No. ABIN393494, Supplier: Log in to see
Antigen
  • S100a1
  • S100A1
  • DKFZp468K0511
  • S100
  • S100-alpha
  • S100A
  • AI266795
  • S100a
  • NEF
  • S100-B
  • S100beta
Epitope
AA 1-76
24
16
6
6
5
4
3
3
2
1
1
1
1
1
1
Reactivity
Human
216
90
69
63
13
10
2
1
1
1
Host
Mouse
154
115
10
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This s100 antibody is un-conjugated
14
13
7
5
5
5
1
Application
Western Blotting (WB)
153
122
109
81
35
21
16
12
10
7
4
1
1
1
1
1
Supplier
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Immunogen S100A1 (NP_006262, 1 a.a. ~ 76 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1D5
Isotype IgG1 kappa
Specificity S100A1 (NP_006262, 1 a.a. ~ 76 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name S100A1 (S100A1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 10546 DA
Gene ID 12406
NCBI Accession NP_006262
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-s100 antibody (S100 Calcium Binding Protein A1) (AA 1-76) (ABIN393494) Western Blot analysis of S100A1 expression in transfected 293T cell line by S100A1 mo...
Immunohistochemistry (IHC) image for anti-s100 antibody (S100 Calcium Binding Protein A1) (AA 1-76) (ABIN393494) anti-S100 Calcium Binding Protein A1 (S100A1) (AA 1-76) antibody (Image 2)
Background publications van Dieck, Lum, Teufel et al.: "S100 proteins interact with the N-terminal domain of MDM2." in: FEBS letters, Vol. 584, Issue 15, pp. 3269-74, 2010 (PubMed).

Marlatt, Spratt, Shaw: "Codon optimization for enhanced Escherichia coli expression of human S100A11 and S100A1 proteins." in: Protein expression and purification, Vol. 73, Issue 1, pp. 58-64, 2010 (PubMed).

Sviatoha, Tani, Kleina et al.: "Immunohistochemical analysis of the S100A1, S100B, CD44 and Bcl-2 antigens and the rate of cell proliferation assessed by Ki-67 antibody in benign and malignant melanocytic tumours." in: Melanoma research, Vol. 20, Issue 2, pp. 118-25, 2010 (PubMed).

DeRycke, Andersen, Harrington et al.: "S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival." in: American journal of clinical pathology, Vol. 132, Issue 6, pp. 846-56, 2009 (PubMed).

Yusenko, Zubakov, Kovacs: "Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours." in: International journal of biological sciences, Vol. 5, Issue 6, pp. 517-27, 2009 (PubMed).