Ephrin A5 (EFNA5) (AA 114-204) antibody

Details for Product No. ABIN393511
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Antigen
Synonyms EFNA5, af1, efl5, rags, eplg7, lerk7, AL-1, AV158822, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS, Lerk7, AF1, EFL5, EPLG7, GLC1M, LERK7
Epitope
AA 114-204
(6), (4), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(45), (32), (29), (13), (13), (12)
Host
Mouse
(42), (5), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(35), (24), (15), (11), (10), (9), (7), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393511
450.00 $
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Immunogen EFNA5 (NP_001953, 114 a.a. ~ 204 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1F12
Isotype IgG2a kappa
Specificity EFNA5 (NP_001953, 114 a.a. ~ 204 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name EFNA5
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 26297 DA
Gene ID 12406
NCBI Accession NP_001953
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Ephrin A5 (EFNA5) (AA 114-204) antibody EFNA5 monoclonal antibody (M01), clone 1F12 Western Blot analysis of EFNA5 expression in NIH/3T3. Detection limit for recombinant GST tagged EFNA5 is approximately 0.03 ng/mL as a capture antibody.
anti-Ephrin A5 (EFNA5) (AA 114-204) antibody (2) anti-Ephrin A5 (EFNA5) (AA 114-204) antibody (Image 2)
Background publications Potkin, Guffanti, Lakatos et al.: "Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease." in: PLoS ONE, Vol. 4, Issue 8, pp. e6501, 2009 (PubMed).

Kalinski, Röpke, Sel et al.: "Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma." in: Human pathology, Vol. 40, Issue 12, pp. 1679-85, 2009 (PubMed).

Sokolowski, Wasserman, Wasserman: "Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters." in: Molecular psychiatry, Vol. 15, Issue 1, pp. 10-1, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Kariuki, Franek, Kumar et al.: "Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus." in: Arthritis research & therapy, Vol. 12, Issue 4, pp. R151, 2010 (PubMed).

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