Cyclin G2 antibody (CCNG2) (AA 1-345)

Details for Product anti-CCNG2 Antibody No. ABIN393525, Supplier: Log in to see
Antigen
  • MGC83944
  • cyclin-G2-like
  • cyclin G2
  • LOC100051425
  • ccng2
  • CCNG2
  • Ccng2
  • LOC100523979
Epitope
AA 1-345
15
15
10
7
4
4
3
1
1
Reactivity
Human
45
19
19
2
2
Host
Mouse
42
3
Clonality (Clone)
Monoclonal ()
Conjugate
This Cyclin G2 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF)
31
19
13
4
4
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen CCNG2 (AAH32518, 1 a.a. ~ 345 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1F9-C11
Isotype IgG1 kappa
Specificity CCNG2 (AAH32518, 1 a.a. ~ 345 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CCNG2 (CCNG2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 38866 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Comment

Background: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunofluorescence (IF) image for anti-Cyclin G2 (CCNG2) (AA 1-345) antibody (ABIN393525) Immunofluorescence of to CCNG2 on HeLa cell .
Background publications Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Cunningham, Vierkant, Sellers, Phelan, Rider, Liebow, Schildkraut, Berchuck, Couch, Wang, Fridley, Gentry-Maharaj, Menon, Hogdall, Kjaer, Whittemore, DiCioccio, Song, Gayther, Ramus, Pharaoh, Goode: "Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis." in: British journal of cancer, Vol. 101, Issue 8, pp. 1461-8, 2009 (PubMed).

Choi, Noh, An, Hong, Park, Baik, Kim, Sohn, Kim: "Expression levels of cyclin G2, but not cyclin E, correlate with gastric cancer progression." in: The Journal of surgical research, Vol. 157, Issue 2, pp. 168-74, 2009 (PubMed).

Xu, Bernaudo, Fu, Lee, Yang, Peng: "Cyclin G2 is degraded through the ubiquitin-proteasome pathway and mediates the antiproliferative effect of activin receptor-like kinase 7." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4968-79, 2008 (PubMed).

Kasukabe, Okabe-Kado, Honma: "Cotylenin A, a new differentiation inducer, and rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2." in: Cancer science, Vol. 99, Issue 8, pp. 1693-8, 2008 (PubMed).