CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) antibody

Details for Product No. ABIN393530
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Synonyms C53, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553, 1810007E24Rik, BC002318, C81486, cdkrap3, fb33h04, fc09c05, id:ibd2920, wu:fb33h04, wu:fc09c05, zgc:86863, CDK5RAP3, cdk5rap3, MGC82350
(29), (22), (22), (12), (12)
(27), (2)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(20), (13), (10), (5), (4), (2)
Pubmed 5 references available
Catalog no. ABIN393530
Quantity 0.1 mg
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Immunogen CDK5RAP3 (AAH09957, 1 a.a. ~ 507 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 1G4
Isotype IgG1 kappa
Specificity CDK5RAP3 (AAH09957, 1 a.a. ~ 507 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CDK5RAP3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 56921 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Cell Structure
Application Notes Western blot = 1:500-1000

Background: Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) antibody Immunofluorescence of monoclonal antibody to CDK5RAP3 on HeLa cell (antibody concentration 10 µg/mL). CDK5RAP3 monoclonal antibody (M01), clone 1G4 Western Blot analysis of CDK5RAP3 expression in A-431.
anti-CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) antibody (2) anti-CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3) antibody (Image 2)
Background publications Stav, Bar, Sandbank: "Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma." in: The International journal of biological markers, Vol. 22, Issue 2, pp. 108-13, 2007 (PubMed).

Wang, An, Mayo et al.: "LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB." in: Cancer cell, Vol. 12, Issue 3, pp. 239-51, 2007 (PubMed).

Jiang, Wu, He et al.: "Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation." in: Cell research, Vol. 19, Issue 4, pp. 458-68, 2009 (PubMed).

Zhuo, Huang, Chen et al.: "Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice." in: Cardiovascular research, Vol. 84, Issue 2, pp. 292-9, 2009 (PubMed).

Wu, Lei, Mei et al.: "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling." in: The Journal of biological chemistry, Vol. 285, Issue 20, pp. 15126-36, 2010 (PubMed).

Hosts (27), (2)
Reactivities (29), (22), (22), (12), (12)
Applications (20), (13), (10), (5), (4), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (2), (1), (1)
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