Oxidative-Stress Responsive 1 (OXSR1) antibody

Antigen: Oxidative-Stress Responsive 1 (OXSR1)

Synonyms: OSR1, KIAA1101, MGC55494, zgc:55494, zgc:77321, DKFZp459B042

Clonality: Monoclonal (2A2-1A2)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN393551

Additional Information

Alternative name: OXSR1

Gene ID: 9943

Immunogen: OXSR1 (AAH08726, 1 a.a. ~ 528 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 2A2-1A2

Description: Other names: KIAA1101, OSR1 oxidative-stress responsive 1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: OXSR1 (AAH08726, 1 a.a. ~ 528 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 58022 DA

Comments:

Background: The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

Immunofluorescence of monoclonal antibody to OXSR1 (AT3161a) on HeLa cell . [antibody concentration 10 ug/ml] OXSR1 monoclonal antibody (M01), clone 2A2-1A2 Western Blot analysis of OXSR1 expression in A-431 ( Cat # L015V1 ).

anti-Oxidative-Stress Responsive 1 (OXSR1) antibody (Image 2)

Publications

Product: Villa, Goebel, Rafiqi et al.: "Structural insights into the recognition of substrates and activators by the OSR1 kinase." in: EMBO reports, Vol. 8, Issue 9, pp. 839-45, 2007 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Richardson, Rafiqi, Karlsson et al.: "Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1." in: Journal of cell science, Vol. 121, Issue Pt 5, pp. 675-84, 2008 (PubMed).

Villa, Deak, Alessi et al.: "Structure of the OSR1 kinase, a hypertension drug target." in: Proteins, Vol. 73, Issue 4, pp. 1082-7, 2008 (PubMed).

Lee, Cobb, Goldsmith: "Crystal structure of domain-swapped STE20 OSR1 kinase domain." in: Protein science : a publication of the Protein Society, Vol. 18, Issue 2, pp. 304-13, 2009 (PubMed).