Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1) (AA 696-796) antibody

Details for Product No. ABIN393567
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Antigen
Synonyms ALDH18A1, ARCL3A, GSAS, P5CS, PYCS, 2810433K04Rik, AI429789, Pycs, cb842, cb899, pycs, sb:cb881, wu:fa91f10, wu:fi05f11, wu:fi17d12
Epitope
AA 696-796
(7), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(23), (5), (5), (2), (2), (1), (1), (1), (1)
Host
Mouse
(16), (4), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(23), (16), (2), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393567
450.00 $
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Immunogen ALDH18A1 (NP_002851, 696 a.a. ~ 796 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B5
Isotype IgG2b kappa
Specificity ALDH18A1 (NP_002851, 696 a.a. ~ 796 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ALDH18A1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 87302 DA
Gene ID 12406
NCBI Accession NP_002851
Research Area Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Aldehyde Dehydrogenase 18 Family, Member A1 (ALDH18A1) (AA 696-796) antibody ALDH18A1 monoclonal antibody (M01), clone 2B5 Western Blot analysis of ALDH18A1 expression in MCF-7.
Background publications Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Hu, Khalil, Zhaorigetu et al.: "Human Delta1-pyrroline-5-carboxylate synthase: function and regulation." in: Amino acids, Vol. 35, Issue 4, pp. 665-72, 2008 (PubMed).

Bicknell, Pitt, Aftimos et al.: "A missense mutation in ALDH18A1, encoding Delta1-pyrroline-5-carboxylate synthase (P5CS), causes an autosomal recessive neurocutaneous syndrome." in: European journal of human genetics : EJHG, Vol. 16, Issue 10, pp. 1176-86, 2008 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Validation Images
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