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P5CS antibody (Aldehyde Dehydrogenase 18 Family, Member A1) (AA 696-796)

Details for Product anti-ALDH18A1 Antibody No. ABIN393567, Supplier: Login to see New
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Synonyms ALDH18A1, ARCL3A, GSAS, P5CS, PYCS, 2810433K04Rik, AI429789, Pycs, cb842, cb899, pycs, sb:cb881, wu:fa91f10, wu:fi05f11, wu:fi17d12
AA 696-796
(15), (11), (9), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(49), (10), (9), (4), (4), (3), (1), (1), (1), (1), (1)
(32), (13), (5)
Clonality (Clone)
Monoclonal ()
This P5CS antibody is un-conjugated
(3), (3), (3), (3), (3), (3)
Western Blotting (WB)
(48), (36), (4), (3), (3), (3), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen ALDH18A1 (NP_002851, 696 a.a. ~ 796 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B5
Isotype IgG2b kappa
Specificity ALDH18A1 (NP_002851, 696 a.a. ~ 796 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ALDH18A1 (ALDH18A1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 87302 DA
Gene ID 12406
NCBI Accession NP_002851
Research Area Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-P5CS antibody (Aldehyde Dehydrogenase 18 Family, Member A1) (AA 696-796) (ABIN393567) ALDH18A1 monoclonal antibody (M01), clone 2B5 Western Blot analysis of ALDH18A1 expre...
Background publications Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Sowa, Bennett, Gygi et al.: "Defining the human deubiquitinating enzyme interaction landscape." in: Cell, Vol. 138, Issue 2, pp. 389-403, 2009 (PubMed).

Bicknell, Pitt, Aftimos et al.: "A missense mutation in ALDH18A1, encoding Delta1-pyrroline-5-carboxylate synthase (P5CS), causes an autosomal recessive neurocutaneous syndrome." in: European journal of human genetics : EJHG, Vol. 16, Issue 10, pp. 1176-86, 2008 (PubMed).

Hu, Khalil, Zhaorigetu et al.: "Human Delta1-pyrroline-5-carboxylate synthase: function and regulation." in: Amino acids, Vol. 35, Issue 4, pp. 665-72, 2008 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Catalog No. ABIN393567
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