Transducin (Beta)-Like 1X-Linked (TBL1X) (AA 478-578) antibody

Details for Product No. ABIN393572
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Synonyms zgc:158242, TBL1X, 5330429M20, Tbl1, RGD1563868, EBI, SMAP55, TBL1
AA 478-578
(9), (3), (3), (2), (2), (1)
(29), (7), (5), (3), (3), (2)
(13), (10), (6)
Clonality (Clone)
Monoclonal ()
(25), (15), (2), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen TBL1X (NP_005638, 478 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B6
Isotype IgG2b kappa
Specificity TBL1X (NP_005638, 478 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TBL1X (TBL1X Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57049 DA
Gene ID 12406
NCBI Accession NP_005638
Research Area Signaling, Cell Signaling, Protein Modifications, Chromatin, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Transducin (Beta)-Like 1X-Linked (TBL1X) (AA 478-578) antibody (ABIN393572) Immunoperoxidase of monoclonal antibody to TBL1X on formalin-fixed paraffin-embedded ...
Immunohistochemistry (IHC) image for anti-Transducin (Beta)-Like 1X-Linked (TBL1X) (AA 478-578) antibody (ABIN393572) anti-Transducin (Beta)-Like 1X-Linked (TBL1X) (AA 478-578) antibody (Image 2)
Background publications Perissi, Scafoglio, Zhang et al.: "TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints." in: Molecular cell, Vol. 29, Issue 6, pp. 755-66, 2008 (PubMed).

Ishii, Kurasawa, Wong et al.: "Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 11, pp. 4179-84, 2008 (PubMed).

Li, Wang: "TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis." in: Nature cell biology, Vol. 10, Issue 2, pp. 160-9, 2008 (PubMed).

Gerlitz, Darhin, Giorgio et al.: "Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization." in: Cell cycle (Georgetown, Tex.), Vol. 4, Issue 11, pp. 1632-40, 2005 (PubMed).

Yoon, Choi, Cole et al.: "Reading and function of a histone code involved in targeting corepressor complexes for repression." in: Molecular and cellular biology, Vol. 25, Issue 1, pp. 324-35, 2004 (PubMed).

Catalog No. ABIN393572
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