|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Transducin (Beta)-Like 1X-Linked (TBL1X) antibody
|Synonyms||EBI, TBL1, SMAP55, TBL1X, tbl1x, MGC158242|
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||TBL1X (NP_005638, 478 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: EBI, TBL1 transducin (beta)-like 1X-linked|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||TBL1X (NP_005638, 478 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||57049 DA|
Background: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Signaling, Cell Signaling, Protein Modifications, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Yoon, Choi, Cole et al.: "Reading and function of a histone code involved in targeting corepressor complexes for repression." in: Molecular and cellular biology, Vol. 25, Issue 1, pp. 324-35, 2004 (PubMed).
Gerlitz, Darhin, Giorgio et al.: "Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization." in: Cell cycle (Georgetown, Tex.), Vol. 4, Issue 11, pp. 1632-40, 2005 (PubMed).
Li, Wang: "TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis." in: Nature cell biology, Vol. 10, Issue 2, pp. 160-9, 2008 (PubMed).
Ishii, Kurasawa, Wong et al.: "Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 11, pp. 4179-84, 2008 (PubMed).
Perissi, Scafoglio, Zhang et al.: "TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints." in: Molecular cell, Vol. 29, Issue 6, pp. 755-66, 2008 (PubMed).
|Hosts||Rabbit (23), Mouse (6), Goat (5)|
|Reactivities||Human (30), Mouse (Murine) (21), Rat (Rattus) (21), Cow (Bovine) (19), Chicken (18), Dog (Canine) (18), Horse (Equine) (18), Monkey (2), Primate (1)|
|Applications||Western Blotting (WB) (16), ELISA (15), Immunofluorescence (IF) (15), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (IHC) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|