Transducin (Beta)-Like 1X-Linked (TBL1X) antibody

Details for Product No. ABIN393572
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Synonyms EBI, TBL1, SMAP55, 5330429M20, Tbl1, RGD1563868, zgc:158242, TBL1X
(30), (16), (15), (13), (13), (12), (6)
(16), (8), (7)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(19), (14), (10), (4), (1)
Pubmed 5 references available
Catalog no. ABIN393572
Quantity 0.1 mg
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Immunogen TBL1X (NP_005638, 478 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B6
Isotype IgG2b kappa
Specificity TBL1X (NP_005638, 478 a.a. ~ 578 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TBL1X
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57049 DA
Gene ID 12406
UniProt NP_005638
Research Area Signaling, Cell Signaling, Protein Modifications, Chromatin, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml

Background: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Transducin (Beta)-Like 1X-Linked (TBL1X) antibody Immunoperoxidase of monoclonal antibody to TBL1X on formalin-fixed paraffin-embedded human cerebral cortex (antibody concentration 1.5 µg/mL). Detection limit for recombinant GST tagged TBL1X is approximately 0.3 ng/mL as a capture antibody.
anti-Transducin (Beta)-Like 1X-Linked (TBL1X) antibody (2) anti-Transducin (Beta)-Like 1X-Linked (TBL1X) antibody (Image 2)
Background publications Yoon, Choi, Cole et al.: "Reading and function of a histone code involved in targeting corepressor complexes for repression." in: Molecular and cellular biology, Vol. 25, Issue 1, pp. 324-35, 2004 (PubMed).

Gerlitz, Darhin, Giorgio et al.: "Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization." in: Cell cycle (Georgetown, Tex.), Vol. 4, Issue 11, pp. 1632-40, 2005 (PubMed).

Li, Wang: "TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis." in: Nature cell biology, Vol. 10, Issue 2, pp. 160-9, 2008 (PubMed).

Ishii, Kurasawa, Wong et al.: "Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 11, pp. 4179-84, 2008 (PubMed).

Perissi, Scafoglio, Zhang et al.: "TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints." in: Molecular cell, Vol. 29, Issue 6, pp. 755-66, 2008 (PubMed).

Hosts (16), (8), (7)
Reactivities (30), (16), (15), (13), (13), (12), (6)
Applications (19), (14), (10), (4), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2)
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