E2F Transcription Factor 6 (E2F6) antibody

Details for Product No. ABIN393573
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Synonyms E2F-6, EMA, E2F6b, AI462434
(57), (34), (31), (3), (2)
(45), (11), (3)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(43), (23), (13), (10), (7), (3), (3), (3), (3), (2)
Pubmed 5 references available
Catalog no. ABIN393573
Quantity 0.1 mg
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Immunogen E2F6 (AAH08348, 1 a.a. ~ 282 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B6-G9
Isotype IgG2a kappa
Specificity E2F6 (AAH08348, 1 a.a. ~ 282 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name E2F6
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 31844 DA
Gene ID 12406
Research Area Signaling, Protein Modifications, Cancer, Transcription Factors, Chromatin, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Tahiliani, Mei, Fang et al.: "The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation." in: Nature, Vol. 447, Issue 7144, pp. 601-5, 2007 (PubMed).

Kikuchi, Shimizu, Wada et al.: "E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1." in: Stem cells (Dayton, Ohio), Vol. 25, Issue 10, pp. 2439-47, 2007 (PubMed).

Xu, Bieda, Jin et al.: "A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members." in: Genome research, Vol. 17, Issue 11, pp. 1550-61, 2007 (PubMed).

Yang, Shu, Zhu et al.: "E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1." in: Molecular biology of the cell, Vol. 19, Issue 9, pp. 3691-700, 2008 (PubMed).

Cunningham, Vierkant, Sellers et al.: "Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis." in: British journal of cancer, Vol. 101, Issue 8, pp. 1461-8, 2009 (PubMed).

Hosts (45), (11), (3)
Reactivities (57), (34), (31), (3), (2)
Applications (43), (23), (13), (10), (7), (3), (3), (3), (3), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (4), (3), (1), (1)
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