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Details for Product No. ABIN393601

Retinoblastoma Binding Protein 4 (RBBP4) antibody

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Antigen
Synonyms
NURF55, RBAP48, mRbAp48, RBBP-4, nurf55, rbap48, rbbp4, xrbbp4, 154659_at, 55, CAF-1, CAF1, CAF1-55, CAF1p55, CG4236, Caf-1, Caf1/p55, Caf1p55, Dmel\\CG4236, MSI1/RbAp48/CAC3/LIN-53, NURF, NURF-55, Nu ... show more
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393601
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen RBBP4 (AAH53904, 1 a.a. ~ 426 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2D7
Isotype IgG1 kappa
Specificity RBBP4 (AAH53904, 1 a.a. ~ 426 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name RBBP4
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 47656 DA
Gene ID 12406
Research Area Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Chromatin, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml Immunofluorescence
Comment

Background: This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2 complex which has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of co-repressor complexes, which is an integral component of transcriptional silencing. It is found among several cellular proteins that bind directly to retinoblastoma protein to regulate cell proliferation. This protein also seems to be involved in transcriptional repression of E2F-responsive genes. Three transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Ishimaru, Arakaki, Yoshida et al.: "Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy." in: The Journal of experimental medicine, Vol. 205, Issue 12, pp. 2915-27, 2008 (PubMed).

Li, Zhang, Yu et al.: "ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis." in: The EMBO journal, Vol. 28, Issue 18, pp. 2763-76, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Li, Margueron, Ku et al.: "Jarid2 and PRC2, partners in regulating gene expression." in: Genes & development, Vol. 24, Issue 4, pp. 368-80, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Alternatives for antigen "Retinoblastoma Binding Protein 4 (RBBP4)", type "Antibodies"
Hosts (36), (21)
Reactivities (55), (26), (24), (14), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applications (47), (21), (19), (15), (14), (10), (10), (8), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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