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Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 251-365) antibody

Details for Product No. ABIN393602
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Antigen
Synonyms erk1/2, sapk4, prkm13, p38delta, Prkm13, MAPK 13, MAPK-13, PRKM13, SAPK4, Serk4, F24B9.3, F24B9_3
Epitope
AA 251-365
(14), (8), (8), (7), (5), (5), (2), (2), (1), (1)
Reactivity
Human
(86), (17), (16), (11), (11)
Host
Mouse
(45), (43)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(76), (39), (25), (19), (10), (10), (9), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393602
450.00 $
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Immunogen MAPK13 (AAH00433, 251 a.a. ~ 365 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2D8
Isotype IgG2b kappa
Specificity MAPK13 (AAH00433, 251 a.a. ~ 365 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAPK13
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 42090 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 251-365) antibody Immunofluorescence of monoclonal antibody to MAPK13 on MCF-7 cell (antibody concentration 10 µg/mL). Western Blot analysis of MAPK13 expression in transfected 293T cell line by MAPK13 monoclonal antibody (M02), clone 2D8. Lane 1: MAPK13 transfected lysate(42.1 KDa). Lane 2: Non-transfected lysate.
anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 251-365) antibody (2) anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 251-365) antibody (Image 2)
Background publications Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Segat, Brandão, Guimarães et al.: "Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment." in: Vaccine, Vol. 28, Issue 10, pp. 2201-6, 2010 (PubMed).

Efimova: "p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis." in: Cell cycle (Georgetown, Tex.), Vol. 9, Issue 3, pp. 498-05, 2010 (PubMed).

Ozawa, Ito, Kato et al.: "Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14." in: Biochemical and biophysical research communications, Vol. 396, Issue 4, pp. 1060-4, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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