Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 231-335) antibody

Details for Product No. ABIN393607
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Antigen
Synonyms MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, Mkk6, Prkmk6, ANQ1, ARABIDOPSIS NQK1, ARABIDOPSIS THALIANA MAP KINASE KINASE 6, ATMKK6, MAP kinase kinase 6, MIK19.2, MIK19_2, MKK3, map2k3, zMKK3
Epitope
AA 231-335
(38), (19), (13), (7), (7), (7), (5), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(147), (91), (82), (12), (12), (12), (1), (1)
Host
Mouse
(130), (27), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(125), (69), (51), (30), (29), (22), (17), (8), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393607
450.00 $
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Immunogen MAP2K6 (AAH12009, 231 a.a. ~ 335 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F2
Isotype IgG2a kappa
Specificity MAP2K6 (AAH12009, 231 a.a. ~ 335 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAP2K6
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 37492 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 231-335) antibody Immunofluorescence of monoclonal antibody to MAP2K6 on HeLa cell (antibody concentration 10 µg/mL). MAP2K6 monoclonal antibody (M02), clone 2F2 Western Blot analysis of MAP2K6 expression in COLO 320 HSR.
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 231-335) antibody (2) anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 231-335) antibody (Image 2)
Background publications Dumka, Puri, Carayol et al.: "Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib." in: Leukemia & lymphoma, Vol. 50, Issue 12, pp. 2017-29, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Huang, Li, Chung: "Activin A induction of erythroid differentiation through MKK6-p38alpha/p38beta pathway is inhibited by follistatin." in: Journal of cellular physiology, Vol. 223, Issue 3, pp. 687-94, 2010 (PubMed).

Sturchler, Feurstein, McDonald et al.: "Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation." in: Biochemistry, Vol. 49, Issue 19, pp. 4094-102, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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