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Details for Product No. ABIN393607

Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) antibody

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Antigen
Synonyms MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, Mkk6, Prkmk6
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN393607
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen MAP2K6 (AAH12009, 231 a.a. ~ 335 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F2
Isotype IgG2a kappa
Specificity MAP2K6 (AAH12009, 231 a.a. ~ 335 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAP2K6
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 37492 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence
Comment

Background: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Dumka, Puri, Carayol et al.: "Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib." in: Leukemia & lymphoma, Vol. 50, Issue 12, pp. 2017-29, 2009 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Huang, Li, Chung: "Activin A induction of erythroid differentiation through MKK6-p38alpha/p38beta pathway is inhibited by follistatin." in: Journal of cellular physiology, Vol. 223, Issue 3, pp. 687-94, 2010 (PubMed).

Sturchler, Feurstein, McDonald et al.: "Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation." in: Biochemistry, Vol. 49, Issue 19, pp. 4094-102, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6)", type "Antibodies"
Hosts (120), (21)
Reactivities (136), (78), (78), (12), (12), (12), (1), (1)
Applications (105), (56), (38), (32), (30), (18), (13), (8), (3), (2), (2), (2), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (34), (13), (13), (5), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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