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Asparagine-Linked Glycosylation 6, alpha-1,3-Glucosyltransferase Homolog (S. Cerevisiae) (ALG6) (AA 25-115) antibody

Details for Product No. ABIN393620, Supplier: Log in to see
Antigen
  • alg6
  • CDG1C
  • CG5091
  • Dalg6
  • Dmel\\CG5091
  • E230028F23Rik
  • zgc:100813
Epitope
AA 25-115
5
3
2
2
Reactivity
Human
19
11
11
3
3
3
2
2
Host
Mouse
14
5
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
18
10
1
Supplier
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Immunogen ALG6 (NP_037471, 25 a.a. ~ 115 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G11
Isotype IgG2a kappa
Specificity ALG6 (NP_037471, 25 a.a. ~ 115 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ALG6 (ALG6 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58181 DA
Gene ID 12406
NCBI Accession NP_037471
Research Area Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Asparagine-Linked Glycosylation 6, alpha-1,3-Glucosyltransferase Homolog (S. Cerevisiae) (ALG6) (AA 25-115) antibody (ABIN393620) ALG6 monoclonal antibody (M09), clone 2G11 Western Blot analysis of ALG6 expression i...
Background publications Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: "The DNA sequence and biological annotation of human chromosome 1. ..." in: Nature, Vol. 441, Issue 7091, pp. 315-21, 2006

Eklund, Sun, Yang, Pasion, Thorland, Freeze: "Congenital disorder of glycosylation Ic due to a de novo deletion and an hALG-6 mutation." in: Biochemical and biophysical research communications, Vol. 339, Issue 3, pp. 755-60, 2005

Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004

Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003

Westphal, Xiao, Kwok, Freeze: "Identification of a frequent variant in ALG6, the cause of Congenital Disorder of Glycosylation-Ic." in: Human mutation, Vol. 22, Issue 5, pp. 420-1, 2003

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