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BUB1B antibody (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast)) (AA 1-130)

Details for Product anti-BUB1B Antibody No. ABIN393631, Supplier: Log in to see
Antigen
  • 31/13
  • AU045529
  • BcDNA:LD23835
  • Bub1
  • bub1
  • BUB1
  • BUB1-like
  • Bub1A
  • bub1b
  • BUB1beta
  • bubr1
  • bubR1
  • BUBR1
  • BubR1
  • BubRI
  • CG7838
  • CG 7838
  • CG14030
  • CG14030/Bub1
  • dBUB1
  • DmBUB1
  • Dmbub1
  • Dmel\\CG7838
  • Dmel\\CG14030
  • hBUBR1
  • l(2)k03113
  • l(2)k06109
  • MAD3L
  • mcl(2)Z1525
  • MVA1
  • SSK1
Epitope
AA 1-130
46
25
12
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
162
60
8
6
2
1
Host
Mouse
93
69
6
Clonality (Clone)
Monoclonal ()
Conjugate
This BUB1B antibody is un-conjugated
4
4
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF)
146
72
54
45
33
26
24
13
11
5
4
3
3
3
2
1
Supplier
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Immunogen BUB1B (AAH18739, 1 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G9
Isotype IgG Mix kappa
Specificity BUB1B (AAH18739, 1 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BUB1B (BUB1B Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 119545 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Comment

Background: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-BUB1B antibody (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast)) (AA 1-130) (ABIN393631) Immunofluorescence of monoclonal antibody to BUB1B on HeLa cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-BUB1B antibody (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast)) (AA 1-130) (ABIN393631) anti-Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) (AA 1-130) antibody (Image 2)
Background publications Suijkerbuijk, van Osch, Bos, Hanks, Rahman, Kops: "Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy." in: Cancer research, Vol. 70, Issue 12, pp. 4891-900, 2010

Gladhaug, Westgaard, Schjølberg, Burum-Auensen, Pomianowska, Clausen: "Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours." in: Histopathology, Vol. 56, Issue 3, pp. 345-55, 2010

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010

Lira, Miranda, Guimarães, Simões, Donadi, Soares, Soares: "BUBR1 expression in benign oral lesions and squamous cell carcinomas: correlation with human papillomavirus." in: Oncology reports, Vol. 23, Issue 4, pp. 1027-36, 2010

Lv, Bu, Jiao, Liu, Zhu, Zhao, Liao, Li, Xu: "LSD1 is required for chromosome segregation during mitosis." in: European journal of cell biology, Vol. 89, Issue 7, pp. 557-63, 2010