Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) (AA 1-130) antibody

Details for Product No. ABIN393631
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Antigen
Synonyms
bub1b, BUB1, BUB1-like, BubR1, BubRI, CG14030, CG14030/Bub1, Dmel\\CG14030, bub1, 31/13, BUBR1, BcDNA:LD23835, Bub1, CG 7838, CG7838, DmBUB1, Dmbub1, Dmel\\CG7838, bubR1, bubr1, dBUB1, l(2)k03113, l(2 ... show more
bub1b, BUB1, BUB1-like, BubR1, BubRI, CG14030, CG14030/Bub1, Dmel\\CG14030, bub1, 31/13, BUBR1, BcDNA:LD23835, Bub1, CG 7838, CG7838, DmBUB1, Dmbub1, Dmel\\CG7838, bubR1, bubr1, dBUB1, l(2)k03113, l(2)k06109, mcl(2)Z1525, BUB1beta, Bub1A, MAD3L, MVA1, SSK1, hBUBR1, AU045529 show less
Epitope
AA 1-130
(20), (9), (7), (3), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(99), (46), (12), (7), (3), (1)
Host
Mouse
(51), (48), (9)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF)
(93), (38), (30), (27), (25), (12), (10), (7), (7), (6), (2), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393631
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Immunogen BUB1B (AAH18739, 1 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G9
Isotype IgG Mix kappa
Specificity BUB1B (AAH18739, 1 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BUB1B
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 119545 DA
Gene ID 12406
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Comment

Background: This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) (AA 1-130) antibody Immunofluorescence of monoclonal antibody to BUB1B on HeLa cell (antibody concentration 10 µg/mL). Immunoperoxidase of monoclonal antibody to BUB1B on formalin-fixed paraffin-embedded human spleen (antibody concentration 1 µg/mL).
anti-Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) (AA 1-130) antibody (2) anti-Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B) (AA 1-130) antibody (Image 2)
Background publications Lv, Bu, Jiao et al.: "LSD1 is required for chromosome segregation during mitosis." in: European journal of cell biology, Vol. 89, Issue 7, pp. 557-63, 2010 (PubMed).

Lira, Miranda, Guimarães et al.: "BUBR1 expression in benign oral lesions and squamous cell carcinomas: correlation with human papillomavirus." in: Oncology reports, Vol. 23, Issue 4, pp. 1027-36, 2010 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Gladhaug, Westgaard, Schjølberg et al.: "Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours." in: Histopathology, Vol. 56, Issue 3, pp. 345-55, 2010 (PubMed).

Suijkerbuijk, van Osch, Bos et al.: "Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy." in: Cancer research, Vol. 70, Issue 12, pp. 4891-900, 2010 (PubMed).

Validation Images
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