You are viewing an incomplete version of our website. Please click to reload the website as full version.

TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 1-505) antibody

Details for Product No. ABIN393632, Supplier: Login to see
Antigen
  • 3'-Tab1
  • MAP3K7IP1
  • 2310012M03Rik
  • Map3k7ip1
  • b2b449Clo
Alternatives
anti-Human TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 antibody for Western Blotting
Epitope
AA 1-505
25
18
16
15
13
8
6
5
5
4
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
169
66
57
2
1
1
1
1
Host
Mouse
151
16
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
10
10
9
6
6
6
4
3
3
3
3
3
3
3
3
Application
Western Blotting (WB)
109
69
34
18
16
13
12
11
7
4
3
1
1
1
Supplier
Login to see
Supplier Product No.
Login to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen MAP3K7IP1 (AAH50554, 1 a.a. ~ 505 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G9
Isotype IgG1 kappa
Specificity MAP3K7IP1 (AAH50554, 1 a.a. ~ 505 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name MAP3K7IP1 (TAB1 Antibody Abstract)
Background The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms: MGC57664, TAB1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1
Molecular Weight 54644 DA
Gene ID 10454
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Pathways TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 1-505) antibody (ABIN393632) MAP3K7IP1 monoclonal antibody (M01), clone 2G9 Western Blot analysis of MAP3K7IP1 exp...
Background publications McGovern, Jones, Taylor et al.: "Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease." in: Human molecular genetics, Vol. 19, Issue 17, pp. 3468-76, 2010 (PubMed).

Scholz, Sidler, Thali et al.: "Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25753-66, 2010 (PubMed).

Potter, Cordell, Barton et al.: "Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways." in: Annals of the rheumatic diseases, Vol. 69, Issue 7, pp. 1315-20, 2010 (PubMed).

Crawford, Yang, Mattaini et al.: "The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28660-73, 2009 (PubMed).

Isono, Kim, Ando et al.: "Suppression of cell invasiveness by periostin via TAB1/TAK1." in: International journal of oncology, Vol. 35, Issue 2, pp. 425-32, 2009 (PubMed).