TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 1-505) antibody

Details for Product No. ABIN393632
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Antigen
Synonyms 3'-Tab1, MAP3K7IP1, 2310012M03Rik, Map3k7ip1, b2b449Clo
Epitope
AA 1-505
(16), (12), (12), (10), (8), (5), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(107), (54), (47), (38), (37), (37), (13), (1), (1)
Host
Mouse
(97), (11), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(69), (39), (30), (15), (14), (11), (8), (5), (2), (1), (1), (1)
Pubmed 5 references available
Quantity 0.05 mg
Options
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Catalog No. ABIN393632
450.00 $
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Immunogen MAP3K7IP1 (AAH50554, 1 a.a. ~ 505 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G9
Isotype IgG1 kappa
Specificity MAP3K7IP1 (AAH50554, 1 a.a. ~ 505 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Alternative Name MAP3K7IP1
Background The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms: MGC57664, TAB1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1
Molecular Weight 54644 DA
Gene ID 10454
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 1-505) antibody MAP3K7IP1 monoclonal antibody (M01), clone 2G9 Western Blot analysis of MAP3K7IP1 expression in 293.
Background publications Isono, Kim, Ando et al.: "Suppression of cell invasiveness by periostin via TAB1/TAK1." in: International journal of oncology, Vol. 35, Issue 2, pp. 425-32, 2009 (PubMed).

Crawford, Yang, Mattaini et al.: "The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28660-73, 2009 (PubMed).

Potter, Cordell, Barton et al.: "Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways." in: Annals of the rheumatic diseases, Vol. 69, Issue 7, pp. 1315-20, 2010 (PubMed).

Scholz, Sidler, Thali et al.: "Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25753-66, 2010 (PubMed).

McGovern, Jones, Taylor et al.: "Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease." in: Human molecular genetics, Vol. 19, Issue 17, pp. 3468-76, 2010 (PubMed).

Validation Images
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