|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) antibody
|Synonyms||MACS, 80K-L, PKCSL, PRKCSL, FLJ14368, FLJ90045, KINC, Macs, marcks, MGC89127, MARCKS, MGC137530|
Alternatives ELISA, Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||MARCKS (NP_002347, 2 a.a. ~ 66 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: 80K-L, FLJ14368, MACS, MRACKS, PKCSL, PRKCSL myristoylated alanine-rich protein kinase C substrate|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||MARCKS (NP_002347, 2 a.a. ~ 66 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||31555 DA|
Background: The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Protein Modifications, Cell Structure|
|Restrictions||For Research Use only|
Eckert, Neuder, Park et al.: "Myristoylated alanine-rich C-kinase substrate (MARCKS) protein regulation of human neutrophil migration." in: American journal of respiratory cell and molecular biology, Vol. 42, Issue 5, pp. 586-94, 2010 (PubMed).
Micallef, Taccone, Mukherjee et al.: "Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression." in: Cancer research, Vol. 69, Issue 19, pp. 7548-56, 2009 (PubMed).
Finlayson, Freeman: "A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis." in: PLoS ONE, Vol. 4, Issue 11, pp. e7833, 2009 (PubMed).
Techasen, Loilome, Namwat et al.: "Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway." in: Cancer science, Vol. 101, Issue 3, pp. 658-65, 2010 (PubMed).
Lin, Fang, Park et al.: "MARCKS and related chaperones bind to unconventional myosin V isoforms in airway epithelial cells." in: American journal of respiratory cell and molecular biology, Vol. 43, Issue 2, pp. 131-6, 2010 (PubMed).