NEDD4 Binding Protein 2 (N4BP2) (AA 1671-1771) antibody

Details for Product No. ABIN393639
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Antigen
Synonyms B3BP, B3bp, Gm868, Gm1791, E430014I16
Epitope
AA 1671-1771
(2)
Reactivity
Human
(2)
Host
Mouse
(2)
Clonality (Clone)
Monoclonal ()
Application
ELISA, Western Blotting (WB)
(2), (2)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN393639
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Immunogen N4BP2 (NP_060647, 1671 a.a. ~ 1771 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2H5
Isotype IgG2b kappa
Specificity N4BP2 (NP_060647, 1671 a.a. ~ 1771 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name N4BP2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 198801 DA
Gene ID 12406
NCBI Accession NP_060647
Research Area Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-NEDD4 Binding Protein 2 (N4BP2) (AA 1671-1771) antibody Detection limit for recombinant GST tagged N4BP2 is approximately 0.03 ng/mL as a capture antibody.
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Zheng, Qin, Yu et al.: "Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population." in: Journal of translational medicine, Vol. 5, pp. 36, 2007 (PubMed).

Lee, Villa, Trojer et al.: "Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination." in: Science (New York, N.Y.), Vol. 318, Issue 5849, pp. 447-50, 2007 (PubMed).

Oshikawa, Sugai, Usami et al.: "Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 15, Issue 3, pp. 123-36, 2008 (PubMed).

Diercks, AB, Daniels et al.: "Solution structure and characterization of the DNA-binding activity of the B3BP-Smr domain." in: Journal of molecular biology, Vol. 383, Issue 5, pp. 1156-70, 2008 (PubMed).

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